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GLIPIZIDE
Product:
GLIPIZIDE
Formulary:
Generic Formulary
Category:
Diabetes
Sub Group:
ORAL ANTIDIABETICS & RELATED DRUGS
International Brand Name:
Dosages:
5 MG
Unit of Packing:
Tablets
In treatment of:
treatment of type Diabetes Mellitus
Adverse Effects:
1. Hypoglycemia
2. Nausea
3. Vomiting
4. Diarrhoea
5. Constipation
6. Headache
7. Paresthesia
8. Hypersensitivity reactions
9. Rashes
10. Photosensitivity
11. Purpura
12. Transient leucopenia
13. Agranulocytosis
Contraiindication:
1. Hypersensitivity to the drug
2. Diabetic ketoacidosis
3. Diabetic coma
4. Renal impairment
5. Hepatic impairment
6. Juvenile diabetes mellitus
7. Stress
Special Precaution:
1. Malnourished and deliberate individuals
2. Strenous exercise and irregular meals may leads to hypoglycemia
3. Hepatic diseases
4. Renal diseases
Interaction:
Hypoglycaemic effect of glipizide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, & Urinary acidifiers.
Hypoglycemic effect of glipizide inhibited by the following drugs: Beta-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers.
Charcoal: Reduces the absorption of glipizide thus reducing its efficacy or toxicity.
Digitalis glycosides: Coadministration results in increased digitalis serum levels.
Servings:
Oral: Starts with 2.5 to 5mg daily; 30 minutes prior to breakfast. Adjust the dosage by increments of 2.5 to 5mg at weekly intervals up to 15mg/day as required.
