ORAL ANTIDIABETICS & RELATED DRUGS
International Brand Name:
In treatment of:
treatment of type Diabetes Mellitus
8. Hypersensitivity reactions
12. Transient leucopenia
1. Hypersensitivity to the drug
2. Diabetic ketoacidosis
3. Diabetic coma
4. Renal impairment
5. Hepatic impairment
6. Juvenile diabetes mellitus
1. Malnourished and deliberate individuals
2. Strenous exercise and irregular meals may leads to hypoglycemia
3. Hepatic diseases
4. Renal diseases
Hypoglycaemic effect of glipizide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, & Urinary acidifiers.
Hypoglycemic effect of glipizide inhibited by the following drugs: Beta-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers.
Charcoal: Reduces the absorption of glipizide thus reducing its efficacy or toxicity.
Digitalis glycosides: Coadministration results in increased digitalis serum levels.
Oral: Starts with 2.5 to 5mg daily; 30 minutes prior to breakfast. Adjust the dosage by increments of 2.5 to 5mg at weekly intervals up to 15mg/day as required.