GLYCERYL TRINITRATE

Product: 
GLYCERYL TRINITRATE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTIANGINALS & CORONORY VASOLIDATORS
International Brand Name: 
Nitroglycerine
Dosages: 
2.6 MG/6.4 mg
Unit of Packing: 
Tablets
In treatment of: 
Longterm management of Stable Angina
Adverse Effects: 
1. Headache 2. Weakness 3. Dizziness 4. Methaemoglobinaemia 5. Flushing 6. Palpitation 7. Orthostatic hypotension 8. Sweating 9. Sub lingual burning 10. Rashes
Contraiindication: 
1. Hypersensitivity to nitrates 2. Severe hypotension 3. Shock 4. Hypertrophic cardiomyopathy 5. Cerebral haemorrhage 6. Early Myocardial infarction(sub lingual) 7. Anaemia 8. Along with phosphodiesterase inhibitors.
Special Precaution: 
1. Gradually withdraw the drug with caution, start therapy with lower doses 2. Hypotension 3. Blood volume depletion 4. Cardio vascular diseases 5. Pulmonary diseases 6. Glaucoma
Interaction: 
Alcohol: Severe hypotension and cardiovascular collapse. Aspirin: Increase serum concentrations of nitrates and their actions. Antihypertensives, TCAs, Phenothiazine, Calcium channel blockers: Marked symptomatic orthostatic hypotension. Sidenafil causes dangerous potentiation of hypotension, myocardial infarction and death Lab Tests: May interfere with the Zlatkis-Zak colour reaction causing a false report of decreased serum cholesterol.
Servings: 
Tablets: 0.5mg at every 3 minutes until therapeutic effect is obtained. I.V.: 5mcg/minute as infusion. Increase with increments of same dose Sustained release Formulations: 2.5 to 6.5mg two to three times daily. Topical: 1.5 to 3cm rubs on three times daily. Use more times if required.

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