HYDROCHLOROTHIAZIDE

Product: 
HYDROCHLOROTHIAZIDE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTI HYPERTENSIVE DRUGS
International Brand Name: 
Aquazide,Microzide,Esidrex,Oretc
Dosages: 
12.5 MG/ 25 mg
Unit of Packing: 
Tablets
In treatment of: 
Management of Hyper Tension(HTN)
Adverse Effects: 
1. Dizziness 2. Blurred vision 3. Confusion 4. Tingling fingers 5. Dry mouth 6. Nausea 7. Diarrhoea 8. Constipation 9. Vomiting 10. Weakness
Contraiindication: 
1. Hyper uricaemia 2. Hyper calcaemia 3. Renal impairment 4. Hepatic impairment 5. Anuria 6. Hypersensitivity to the drug 7. Hyper sensitivity to sulfonamides 8. Fluid and electrolyte imbalance
Special Precaution: 
1. Gout 2. Diabetes mellitus 3. Renal impairment 4. Hepatic impairment 5. Monitor and correct Fluid and electrolyte imbalance 6. Hyper parathyroidism 7. Cirrhosis
Interaction: 
Cholestyramine & Colestipol: decrease absorption of hydrochlorothiazide. Diazoxide: Additive action - may cause hyperglycemia, hyperuricaemia and hypotension. Digitalis: Diuretics induced hypokalaemia may precipitate digitalis toxicity. Lithium: Hydrochlorothiazide potentiates therapeutic and toxic effects by increasing its renal excretion. Frusemide: Synergy leading to profound diuresis and greater than predicted electrolyte loss. Non-depolarizing muscle relaxants: Diuretics induced hypokalaemia enhances efficacy. Sulfonylureas: Efficacy decreased due to hydrochlorothiazide induced glucose intolerance.
Servings: 
Adults: Hypertension: 25mg once daily or in divided doses. Increased to 50mg if required; depending up on the patient`s response. Children: 1mg/kg single daily dose. Oedema: Adults: Starts with 25 to 50mg. Increased the dose until desired response is obtained. Maximum dose: 200mg/day Maintenance dosage: 25 to 100mg daily or on alternate days. Children: 1mg/kg single daily dose or 1 to 3mg/kg/day in two divided doses

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