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INDOMETACIN
Product:
INDOMETACIN
Formulary:
Generic Formulary
Category:
Musculo Skeletol Disorder
Sub Group:
NASAIDS(Non Sterodial Anti Inflamatory Drugs)
International Brand Name:
Indocin,Indocid,Indochron ER, Indocin SR
Dosages:
25 MG
Unit of Packing:
Tablets
In treatment of:
Mgt of chronic musculoskeletal & joint disorders
Adverse Effects:
1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Peptic ulcer
9.Dyspepsia
10.Headache
11.Depression
12.Dizziness
13.Confusion
14.Somnolence
15.Ataxia
16.Psychoses
17.Vertigo
18.Rash
Contraiindication:
1.Hypersensitivity to Indomethacin and other Non steroidal anti inflammatory drugs(NSAID)
2.Peptic ulcer
3.Severe renal impairment
4.Suppositories in patients with proctitis and hemorrhoids.
Special Precaution:
1.Hepatic impairment
2.Renal impairment
3.Cardiovascular diseases
4.Gastrointestinal diseases
5.Parkinsonism
6.Epilepsy
7.Psychiatric illness
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
Interaction:
Anticoagulants: May prolong prothrombin time. Instruct patients to watch for signs & symptoms of bleeding.
Beta-Blockers: Antihypertensive effect may be blunted.
Cyclosporine: Nephrotoxicity of both agents may be increased.
Digoxin: Serum digoxin levels may be increased by ibuprofen and indomethacin.
Hydantoins: Serum hydantoin levels increased resulting in increased pharmacological and toxic effects.
Lithium: Serum lithium levels may be increased.
Loop diuretics: Decreased effects.
Methotrexate: Risk of methotrexate toxicity (bone marrow suppression, nephrotoxicity, stomatitis) may be increased.
Salicylates: Displaces NSAIDs from serum binding sites resulting in decreased plasma concentrations of NSAIDs and increased incidence of GI effects.
Sympathomimetics: Indomethacin coadministration may result in increased blood pressure.
Thiazide diuretics: Naproxen and indomethacin may cause decreased antihypertensive and diuretic action.
Servings:
DOSAGE:
Adult: 50 - 200 mg / day in 2 - 4 divided doses.
Rheumatoid arthritis, ankylosing spondylitis and Osteoarthritis: 50 - 75 mg / day in 2 - 3 divided doses with food or antacids. Dose can be gradually increased every week until sufficient response is obtained.
Maximum dose: 200 mg / day
Gouty arthritis: 150 mg / day in 3 divided doses until pain is tolerable. Then reduce the dose and suddenly stop the drug.
Dysmenorrhoea: 75 mg / day in 3 divided doses with food or antacids.
Painful shoulder: 75 -150 mg / day in 3 - 4 divided doses for 1 - 2 week
Migraine: 50mg 3 - 4 times daily
Children: 1 mg / kg / day in divided doses.
Maximum dose: 4 mg / kg / day in divided doses.
Children below 14 years: not recommended
