INDOMETACIN

Product: 
INDOMETACIN
Formulary: 
Generic Formulary
Category: 
Musculo Skeletol Disorder
Sub Group: 
NASAIDS(Non Sterodial Anti Inflamatory Drugs)
International Brand Name: 
Indocin,Indocid,Indochron ER, Indocin SR
Dosages: 
25 MG
Unit of Packing: 
Tablets
In treatment of: 
Mgt of chronic musculoskeletal & joint disorders
Adverse Effects: 
1.Nausea 2.Vomiting 3.Anorexia 4.Diarrhoea 5.Gastrointestinal bleeding 6.Abdominal distress 7.Constipation 8.Peptic ulcer 9.Dyspepsia 10.Headache 11.Depression 12.Dizziness 13.Confusion 14.Somnolence 15.Ataxia 16.Psychoses 17.Vertigo 18.Rash
Contraiindication: 
1.Hypersensitivity to Indomethacin and other Non steroidal anti inflammatory drugs(NSAID) 2.Peptic ulcer 3.Severe renal impairment 4.Suppositories in patients with proctitis and hemorrhoids.
Special Precaution: 
1.Hepatic impairment 2.Renal impairment 3.Cardiovascular diseases 4.Gastrointestinal diseases 5.Parkinsonism 6.Epilepsy 7.Psychiatric illness 8.Cautioned against driving, operating or activities requiring concentration 9.Avoid alcohol
Interaction: 
Anticoagulants: May prolong prothrombin time. Instruct patients to watch for signs & symptoms of bleeding. Beta-Blockers: Antihypertensive effect may be blunted. Cyclosporine: Nephrotoxicity of both agents may be increased. Digoxin: Serum digoxin levels may be increased by ibuprofen and indomethacin. Hydantoins: Serum hydantoin levels increased resulting in increased pharmacological and toxic effects. Lithium: Serum lithium levels may be increased. Loop diuretics: Decreased effects. Methotrexate: Risk of methotrexate toxicity (bone marrow suppression, nephrotoxicity, stomatitis) may be increased. Salicylates: Displaces NSAIDs from serum binding sites resulting in decreased plasma concentrations of NSAIDs and increased incidence of GI effects. Sympathomimetics: Indomethacin coadministration may result in increased blood pressure. Thiazide diuretics: Naproxen and indomethacin may cause decreased antihypertensive and diuretic action.
Servings: 
DOSAGE: Adult: 50 - 200 mg / day in 2 - 4 divided doses. Rheumatoid arthritis, ankylosing spondylitis and Osteoarthritis: 50 - 75 mg / day in 2 - 3 divided doses with food or antacids. Dose can be gradually increased every week until sufficient response is obtained. Maximum dose: 200 mg / day Gouty arthritis: 150 mg / day in 3 divided doses until pain is tolerable. Then reduce the dose and suddenly stop the drug. Dysmenorrhoea: 75 mg / day in 3 divided doses with food or antacids. Painful shoulder: 75 -150 mg / day in 3 - 4 divided doses for 1 - 2 week Migraine: 50mg 3 - 4 times daily Children: 1 mg / kg / day in divided doses. Maximum dose: 4 mg / kg / day in divided doses. Children below 14 years: not recommended

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