Musculo Skeletol Disorder
NASAIDS(Non Sterodial Anti Inflamatory Drugs)
International Brand Name:
Indocin,Indocid,Indochron ER, Indocin SR
In treatment of:
Mgt of chronic musculoskeletal & joint disorders
1.Hypersensitivity to Indomethacin and other Non steroidal anti inflammatory drugs(NSAID)
3.Severe renal impairment
4.Suppositories in patients with proctitis and hemorrhoids.
8.Cautioned against driving, operating or activities requiring concentration
Anticoagulants: May prolong prothrombin time. Instruct patients to watch for signs & symptoms of bleeding.
Beta-Blockers: Antihypertensive effect may be blunted.
Cyclosporine: Nephrotoxicity of both agents may be increased.
Digoxin: Serum digoxin levels may be increased by ibuprofen and indomethacin.
Hydantoins: Serum hydantoin levels increased resulting in increased pharmacological and toxic effects.
Lithium: Serum lithium levels may be increased.
Loop diuretics: Decreased effects.
Methotrexate: Risk of methotrexate toxicity (bone marrow suppression, nephrotoxicity, stomatitis) may be increased.
Salicylates: Displaces NSAIDs from serum binding sites resulting in decreased plasma concentrations of NSAIDs and increased incidence of GI effects.
Sympathomimetics: Indomethacin coadministration may result in increased blood pressure.
Thiazide diuretics: Naproxen and indomethacin may cause decreased antihypertensive and diuretic action.
Adult: 50 - 200 mg / day in 2 - 4 divided doses.
Rheumatoid arthritis, ankylosing spondylitis and Osteoarthritis: 50 - 75 mg / day in 2 - 3 divided doses with food or antacids. Dose can be gradually increased every week until sufficient response is obtained.
Maximum dose: 200 mg / day
Gouty arthritis: 150 mg / day in 3 divided doses until pain is tolerable. Then reduce the dose and suddenly stop the drug.
Dysmenorrhoea: 75 mg / day in 3 divided doses with food or antacids.
Painful shoulder: 75 -150 mg / day in 3 - 4 divided doses for 1 - 2 week
Migraine: 50mg 3 - 4 times daily
Children: 1 mg / kg / day in divided doses.
Maximum dose: 4 mg / kg / day in divided doses.
Children below 14 years: not recommended