Generic Formulary
Infections & Infestations
Sub Group: 
International Brand Name: 
300MG+VIT6 10MG
Unit of Packing: 
In treatment of: 
Primary treatment of Pulmonary and extrapulomonary Tuberculosis
Adverse Effects: 
1. Nausea 2 .Vomiting 3. Gastric upset 4. Peripheral neuritis 5. Optic neuritis 6. Atrophy 7. Paresthesia 8. Allergy 9. Fever 10.Rash 11.Malaise 12.Lymph adenopathy 13.Jaundice
1. Hypersensitivity to Isoniazide 2. Drug induced hepatic disease
Special Precaution: 
1.Renal impairment 2.Hepatic impairment 3.Alcoholism 4.Epilepsy
Alcohol: Regular ingestion of alcohol is associated with higher incidence of INH-related hepatitis. Aluminium Salts: Oral absorption of INH reduced leading to decreased serum levels. Oral anticoagulants: Efficacy of oral anticoagulants increased. Benzodiazepines: Activity of benzodiazepines that undergo oxidative metabolism is possibly increased. Carbamazepine: Isoniazid hepatotoxicity & carbamazepine toxicity may occur from concurrent use. Cycloserine: Increased cycloserine related CNS side effects, especially dizziness. Disulfiram: Acute behavioural and co-ordination changes. Enflurane: High output renal failure may occur. Halothane: Hepatotoxicity and hepatic encephalopathy. Hydantoins: Serum hydantoin levels increased leading to enhanced pharmacological and toxic effects. Ketoconazole: Serum concentrations of ketoconazole decreased possibly leading to resistance to antifungal treatment. Rifampicin: Higher incidence of hepatotoxicity than with either agent alone. Food: Interaction with tyramine-containing foods since INH has MAOI activity. Exaggerated response (headache, palpitation, sweating, hypotension, flushing, itching) to foods containing histamine (tuna, sauerkraut juice, yeast extract).
Adult: 200 - 300 mg once daily for 6 months to 24 months depending on the severity of infection Children:5 - 10 mg / kg body weight / day for 6 months to 24 months depending on the severity of infection.

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