ISONIAZID

Product: 
ISONIAZID
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTITUBERCULOUS
International Brand Name: 
Loniazid,Mydrazid
Dosages: 
300MG+VIT6 10MG
Unit of Packing: 
Tablets
In treatment of: 
Primary treatment of Pulmonary and extrapulomonary Tuberculosis
Adverse Effects: 
1. Nausea 2 .Vomiting 3. Gastric upset 4. Peripheral neuritis 5. Optic neuritis 6. Atrophy 7. Paresthesia 8. Allergy 9. Fever 10.Rash 11.Malaise 12.Lymph adenopathy 13.Jaundice
Contraiindication: 
1. Hypersensitivity to Isoniazide 2. Drug induced hepatic disease
Special Precaution: 
1.Renal impairment 2.Hepatic impairment 3.Alcoholism 4.Epilepsy
Interaction: 
Alcohol: Regular ingestion of alcohol is associated with higher incidence of INH-related hepatitis. Aluminium Salts: Oral absorption of INH reduced leading to decreased serum levels. Oral anticoagulants: Efficacy of oral anticoagulants increased. Benzodiazepines: Activity of benzodiazepines that undergo oxidative metabolism is possibly increased. Carbamazepine: Isoniazid hepatotoxicity & carbamazepine toxicity may occur from concurrent use. Cycloserine: Increased cycloserine related CNS side effects, especially dizziness. Disulfiram: Acute behavioural and co-ordination changes. Enflurane: High output renal failure may occur. Halothane: Hepatotoxicity and hepatic encephalopathy. Hydantoins: Serum hydantoin levels increased leading to enhanced pharmacological and toxic effects. Ketoconazole: Serum concentrations of ketoconazole decreased possibly leading to resistance to antifungal treatment. Rifampicin: Higher incidence of hepatotoxicity than with either agent alone. Food: Interaction with tyramine-containing foods since INH has MAOI activity. Exaggerated response (headache, palpitation, sweating, hypotension, flushing, itching) to foods containing histamine (tuna, sauerkraut juice, yeast extract).
Servings: 
Adult: 200 - 300 mg once daily for 6 months to 24 months depending on the severity of infection Children:5 - 10 mg / kg body weight / day for 6 months to 24 months depending on the severity of infection.

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