ISOSORBIDE MONONITERATE

Product: 
ISOSORBIDE MONONITERATE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTIANGINALS & CORONORY VASOLIDATORS
International Brand Name: 
Imdur, Chemydur
Dosages: 
10 MG/20 mg/40 mg
Unit of Packing: 
Tablets
In treatment of: 
Longterm management of Stable Angina & Heart Failure
Adverse Effects: 
1. Headache 2. Weakness 3. Dizziness 4. Methaemoglobinaemia 5. Flushing 6. Palpitation 7. Orthostatic hypotension 8. Sweating 9. Sub lingual burning 10. Rashes
Contraiindication: 
1. Myocardial infarction 2. Hypersensitivity to nitrates 3. Severe hypotension 4. Shock 5. Along with phosphodiesterase inhibitors
Special Precaution: 
1. Gradually withdraw the drug with caution start therapy with lower doses 2. Hypotension 3. Blood volume depletetion 4. Cerebral haemorrhage 5. Glaucoma
Interaction: 
Alcohol: Severe hypotension and cardiovascular collapse. Aspirin: Increase serum concentrations of nitrates and their actions. Antihypertensives, TCAs, Phenothiazine, Calcium channel blockers: Marked symptomatic orthostatic hypotension. Lab Tests: May interfere with the Zlatkis-Zak colour reaction causing a false report of decreased serum cholesterol.
Servings: 
10 to 20mg two times daily with 7 hours apart; and first dose in morning. Sustained release forms: 30 to 60mg once daily; Increased to 120mg once daily if required.

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