ANTIANGINALS & CORONORY VASOLIDATORS
International Brand Name:
In treatment of:
Longterm management of Stable Angina & Heart Failure
7. Orthostatic hypotension
9. Sub lingual burning
1. Myocardial infarction
2. Hypersensitivity to nitrates
3. Severe hypotension
5. Along with phosphodiesterase inhibitors
1. Gradually withdraw the drug with caution start therapy with lower doses
3. Blood volume depletetion
4. Cerebral haemorrhage
Alcohol: Severe hypotension and cardiovascular collapse.
Aspirin: Increase serum concentrations of nitrates and their actions.
Antihypertensives, TCAs, Phenothiazine, Calcium channel blockers: Marked symptomatic orthostatic hypotension.
Lab Tests: May interfere with the Zlatkis-Zak colour reaction causing a false report of decreased serum cholesterol.
10 to 20mg two times daily with 7 hours apart; and first dose in morning.
Sustained release forms: 30 to 60mg once daily; Increased to 120mg once daily if required.