ISOTRETINOIN

Product: 
ISOTRETINOIN
Formulary: 
Generic Formulary
Category: 
Skin
Sub Group: 
ACNE
International Brand Name: 
Accutane,Amnesteem , Claravis, Clarus,Izotek , Oratane , Roaccutane , Sotret ,Isotrex, Isotrexin
Dosages: 
10 MG/20 mg
Unit of Packing: 
Capsule
In treatment of: 
ACNE
Adverse Effects: 
1.Dryness of the skin nose, mouth and eyes 2.Epidermal fragility 3.Hyper pigmentation 4.Itching 5.Epistaxis (nosebleeds) 6.Chilitis 7.Blurred vision 8.Depression 9.Loss of appetite 10.Bloody diarrhea 11.Abdominal discomfort 12.Pain when swallowing 13.Heartburn 14.Yellowing of the skin or eyes or persistently dark urine 15.Severe headache 16.Dizziness 17.Seizures 18.Nausea 19.Vomiting 20.Joint or muscle pain or bone problems 21.Hearing problems 22.Depression
Contraiindication: 
1.Contraindicated to Isotretinoin
Special Precaution: 
1.Avoid exposure to sunlight and ultraviolet light 2.Avoid concurrent administration of Vitamin A 3.Avoid driving at night
Interaction: 
Alcohol: Etretinate formed in presence of alcohol. Antibacterials: Possible increased risk of benign intracranial hypertension with tetracyclines. Warfarin: Possible reduction in anticoagulant effect. Antiepileptics: Plasma concentration of carbamazepine may be reduced. Cytotoxic drugs: Plasma concentration of methotrexate may be increased. Oestrogens and progestogens: Contraceptive efficacy of low dose progestogens may be reduced but no effect on combined oral contracetives. Vitamins: Risk of hypervitaminosis with vitamin A.
Servings: 
Oral Adult: 0.5-1 mg/kg body weight/day in 2 divided doses with meals for 4-5 months

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