International Brand Name:
Accutane,Amnesteem , Claravis, Clarus,Izotek , Oratane , Roaccutane , Sotret ,Isotrex, Isotrexin
1.Dryness of the skin nose, mouth and eyes
9.Loss of appetite
12.Pain when swallowing
14.Yellowing of the skin or eyes or persistently dark urine
20.Joint or muscle pain or bone problems
1.Contraindicated to Isotretinoin
1.Avoid exposure to sunlight and ultraviolet light
2.Avoid concurrent administration of Vitamin A
3.Avoid driving at night
Alcohol: Etretinate formed in presence of alcohol.
Antibacterials: Possible increased risk of benign intracranial hypertension with tetracyclines.
Warfarin: Possible reduction in anticoagulant effect.
Antiepileptics: Plasma concentration of carbamazepine may be reduced.
Cytotoxic drugs: Plasma concentration of methotrexate may be increased.
Oestrogens and progestogens: Contraceptive efficacy of low dose progestogens may be reduced but no effect on combined oral contracetives.
Vitamins: Risk of hypervitaminosis with vitamin A.
Adult: 0.5-1 mg/kg body weight/day in 2 divided doses with meals for 4-5 months