ANALGESICS & ANTIPYRETICS
International Brand Name:
In treatment of:
Short term mgt of moderate to severe post opeartive pain
6. Transient scalp tingling
7. Orthostatic hypotension
8. Ventricular arrhythmias
9. Nasal stuffiness
10. Broncho spasm
13. Muscle spasm
14. Toxic myopathy
15. Dry mouth
17. Gastric irritation
19. Dry mouth
1. Hypersensitivity to this drug
2. Peptic ulcer
3. As a prophylactic analgesic before surgery; pregnancy and lactation
5. In elderly patient there is usually hepatic or renal dysfunction
6. Coagulation disorder
1. Hepatic dysfunction
2. Renal dysfunction and in to be used with caution
3. GI disease
4. Bleeding disorders
5. Patients with hypersensitivity to other Non Steroidal Anti Inflammatory Drugs
Anticoagulants: May prolong prothrombin time.
Beta blockers: Antihypertensive effect may be impaired.
Cyclosporine: Nephrotoxicity of both agents may be increased.
Lithium: Serum lithium levels may be increased resulting in toxicity.
Hydantoins: Serum hydantoins levels resulting in increased efficacy and toxic effects.
Methotrexate: Risk of methotrexate toxicity (stomatitis, bone marrow suppression, nephrotoxicity) increased.
Aspirin: Plasma concentration of ketorolac may be decreased and may increase the incidence of GI effects.
Adults-Initially 60mg i.m. or 30mg i.v. as a single dose, or 30 mg i.m or i.v. every 6 hrs. In the case of renal impaired patient, initially 30mg i.m .or 15mg i.v. as a single doses or multiple doses of 15mg i.m. or i.v.every 6 hrs.
Adults- 20mg as a single dose followed by 10mg every 4 to 6 hrs. In the case of renal impaired patients 10mg as a single dose, followed by 10mg every 4 to 6 hrs.