LABETALOL

Product: 
LABETALOL
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTI HYPERTENSIVE DRUGS
International Brand Name: 
Normodyne,Tradate,Normozyle
Dosages: 
20 MG/4 ML
Unit of Packing: 
Amp
In treatment of: 
Management of Hyper Tension(HTN)
Adverse Effects: 
1. Gastrointestinal disturbances 2. Diarrhoea 3. Dry mouth 4. Cholestasis 5. Fluid retention 6. Nervousness 7. Sexual dysfunction 8. Muscle cramps 9. Depression 10. Dyspnoea 11. Drowsiness 12. Headache 13. Paraesthesia 14. Visual impairment 15. Rash 16. Alopecia 17. Urinary retention 18. Long term therapy produces antinuclear antibodies
Contraiindication: 
1. Gastrointestinal disturbances 2. Diarrhoea 3. Dry mouth 4. Cholestasis 5. Fluid retention 6. Nervousness 7. Sexual dysfunction 8. Muscle cramps 9. Depression 10. Dyspnoea
Special Precaution: 
1.Cardiac failure 2.Peripheral vascular diseases 3.Hepatic impairment 4. The drug should be gradually withdraw with caution 5. Use with caution in chronic obstructive pulmonary diseases 6. Diabetes mellitus 7. Hyperthyroidism 8. Postural hypotension
Interaction: 
Tricyclic antidepressants: Increased incidence of tremor. Cimetidine: Bioavailability of labetalol is enhanced. Beta-adrenergic agonists: Can decrease the bronchodilator effects of these drugs in patients with bronchospasm. Halothane: Significant myocardial depression with I.V. labetalol. Don`t use high concentration (3% or above) of halothane. Nitroglycerin: Labetalol blunts reflex tachycardia produced by nitroglycerin without preventing its hypotensive effect. Lab.tests: False increase in urinary catecholamine levels by nonspecific trihydroxy-indole reaction. Reversible increase in serum transaminases.
Servings: 
Phaeochromocytoma & Hypertension: 100mg orally 12th hourly. Increases the dosage by 100mg up to 600mg 12th hourly at every 2-3 days intervals depending up on patient`s response Maximum dose: 2400mg Hypertensive emergencies, Severe hypertension, & Clonidine withdrawal : Starts with 20mg I.V. bolus over 2minutes. Increases the dosage at every 10minutes intervals by 40 to 80mg up to 300mg based on patient`s response.

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