Generic Formulary
Cardio Vascular System
Sub Group: 
International Brand Name: 
Lidocaine and Xylocaine
25MGx2 ML
Unit of Packing: 
Vial- 2 ml
In treatment of: 
Intravenous:treatment of ventricular arrhythmias in advanced cardiac life support for cardiac arrest due to ventricular fibrillation and pulseless ventricular Tachycardia
Adverse Effects: 
Drowsiness; Paresthesia; Blurred vision; Nausea; Nystagmus; Disorientation; Twitching; Fits; Hypotension; Cardiac depression; Bradycardia; Asystole; Ventricular fibrillation; Cardiac arrest; Respiratory arrest
Hypersensitivity to the drug ; AV block; SA block; Intra ventricular block; Cardiac decompensation ;Supra ventricular arrhythmia; Conduction disturbances; Strokes Adams Syndrome; Wolff Parkinson White syndrome; Infection or inflammation in puncture region; Septicemia; Severe hypertension; Spinal deformities; Neurological disorders
Special Precaution: 
Hepatic impairment; Renal impairment; Deliberate individuals; Complete or second degree heart block; Sinus Bradycardia; Heart failure; Hypotension; Shock; Malignant hyperthermia; Monitor ECG with caution during therapy
Propranolol: Increased lignocaine levels resulting in toxicity. Procainamide: Additive cardiodepressent action may occur with potential for conduction abnormalities.Cimetidine: Decreased lignocaine clearance with possible toxicity.Tocainide: Increased incidence of adverse reactions.Adrenaline: Reduces the absorption of lignocaine.
Ventricular arrhythmia: 1 to 1.5mg/kg I.V. bolus at a rate of 25 to 50mg/minute. Repeat he bolus with same dose or 0.5 to 0.75mg/kg every 5 to 10minutes until arrhythmia subsides. Do not exceed 300mg total bolus during a 1hour period. Maintenance dosage: Constant infusion of 1 to 4mg/minute. After 24 hour reduce rate of infusion by one half.Local anaesthesia of skin or mucous membrane: Apply 2% to 5% solution or ointment or 15ml Xylocaine viscous every 3 to 4hours.Local anaesthesia in the male or female urethra: Instill about 15ml (male) or 3 to 5ml to female urethra.Pain, Burning, or Itching: Apply topical agent liberally.As injection as procedural anesthetic: 4.4mg/kg; but not more than 300mg total. Along with epinephrine; 7mg/kg; but not more than 500mg total. For continuous epidural or caudal anesthesia, maximum doses should not administer at intervals less than 90 minutes.

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