LOMUSTINE

Product: 
LOMUSTINE
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
CeeNU
Dosages: 
2 mg/5 mg/50 mg
Unit of Packing: 
Tablet
In treatment of: 
Treatment of Brain Tumours,Resistant or relapsed Hodgkin' Lymphoma,malignant Melanoma,Renal Carcinoma,Lung Cancer,Colon Cancer
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. Sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blood in urine or in stool 14. Cough or hoarseness 15. Fever 16. Chills 17. Lower back or side pain 18. Painful or difficult urination 19. Pinpoint red spot on skin 20. Slurred speech 21. Swelling on leg or lower leg 22. Shortness of breath 23. Pulmonary fibrosis 24. Hepatotoxicity 25. Nephrotoxicity 26. Stomatitis 27. Disorientation 28. Lethargy 29. Ataxia 30. Thrombocytopenia 31. Leucopenia 32. Bone marrow suppression
Contraiindication: 
1. Hypersensitivity to the drug 2. Blood disorder
Special Precaution: 
1. Decreased platelet, WBC or RBC count 2. Renal impairment 3. Treatment with myelosupressive agents
Interaction: 
Theophylline: Causes leucopenia and thrombocytopenia.
Servings: 
Oral- Adults- 130mg/metre square as single dose every 6 weeks. Child- 75 to 150mg/metre square as single dose every 6 weeks.

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