International Brand Name:
In treatment of:
Management of Hyper Tension(HTN)
5. Chest pain
6. Sore throat
10. Elevated liver enzyme levels
1. Hypersensitivity to the drug
4.Volume depleted individuals
5.Monitor serum potassium levels and avoid use along with potassium sparing diuretics
6. Avoid driving or operating heavy machinery during therapy
7. Avoid alcohol use during therapy
Diuretics, other antihypertensives: Potentiate the hypotensive effect of losartan.
Potassium sparing diuretics, potassium suppliments: Risk of hyperkalaemia.
NSAIDs: May blunt hypotensive effect of losartan.
Cytochrome P450 inhibitors like ketoconazole: Increase in AUC of losartan by 18 % but has no effect on its active metabolite.
Phenobarbital: Results in 20% reduction in AUC of losartan and its active metabolite.
25 to 50mg once daily. Gradually increases up to 100mg once daily or as two divided doses.