MERCAPTOPURINE

Product: 
MERCAPTOPURINE
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Purinethol
Dosages: 
50 mg
Unit of Packing: 
Tablet
In treatment of: 
Treatment of acute Lymphoblastic Leukaemia and Myeloid Lukaemias
Adverse Effects: 
1. Nausea 2. Vomiting 3. Difficulty in breathing 4. Closing of the throat 5. Bone marrow suppression 6. Bruising or unusual bleeding 7. Tarry stools 8. Fever 9. Chills 10. Congestive heart failure 11. Diarrhea 12. Loss of appetite 13. Facial flushing 14. Darkening of skin and nails 15. Alopecia 16. Red urine 17. Leucopenia 18. Hyperurecemia 19. Pancreatitis 20. Hepatotoxicity 21. Jaundice 22. Thrombocytopenia
Contraiindication: 
1. Hypersensitivity to the drug 2. Prior resistance to mercaptopurine and thioguanine
Special Precaution: 
1. Nausea 2. Vomiting 3. Difficulty in breathing 4. Closing of the throat 5. Bone marrow suppression 6. Bruising or unusual bleeding 7. Tarry stools 8. Fever 9. Chills 10. Congestive heart failure 11. Diarrhea 12. Loss of appetite 13. Facial flushing 14. Darkening of skin and nails 15. Alopecia 16. Red urine 17. Leucopenia 18. Hyperurecemia 19. Pancreatitis 20. Hepatotoxicity 21. Jaundice 22. Thrombocytopenia
Interaction: 
Allopurinol: Delayed catabolism of mercaptopurine resulting in severe toxicity. Dose of mercaptopurine should be reduced to one third to one quarter of usual dose. Other myelosuppressive agents: Enhance anti-neoplastic effect of mercaptopurine, dose of mercaptopurine may need to be reduced. Trimethoprim-sulfamethoxazole: May result in enhanced bone marrow suppression.
Servings: 
Oral- Adult- 2.5 mg/kg/day as a single dose. If there is no response increase the dose up to 5mg/kg/day. 1.5-2.5 mg/kg/day as a maintenance dose. Children- 2.5mg/kg/day. 1.5 - 2.5 mg/kg/day as a maintenance dose.

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