METHYLDOPA

Product: 
METHYLDOPA
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTI HYPERTENSIVE DRUGS
International Brand Name: 
Aldomet,Dopamet,Novomedopa
Dosages: 
250 MG
Unit of Packing: 
Tablets
In treatment of: 
Management of Hyper Tension(HTN)
Adverse Effects: 
1.Sedation 2.Mental depression 3.Dryness of mouth, eyes & nose 4.Cognitive impairment 5.Impotence 6.Dizziness 7.Insomnia 8.Constipation 9.Electrolyte imbalance 10.Postural hypotension
Contraiindication: 
1.Hypersensitivity to the drug 2.Hepatitis, Cirrhosis or other hepatic disorders 3.Depression 4.Pheochromocytoma 5.Postural hypotension 6.Porphyria 7.Concurrent administration with MAO inhibitors
Special Precaution: 
1.Renal impairment 2.Hepatic impairment 3.Haemolytic anaemia 4.Some individuals may show +ve direct coomb`s test 5.Parkinsonism 6.Asses blood count and liver function 7.Avoid driving or other jobs requiring mental concentration
Interaction: 
Haloperidol: Adverse mental symptoms and high incidence of sedation. Levodopa: Effects of levodopa potentiated. Corticosteroids & Carbenoxolone: Antagonism of hypotensive effects. Propranolol: Paradoxical hypertensive effect. Diuretics: Enhanced hypotensive effect. Nitrates: Enhanced hypotensive effects. Sympathomimetics: Methyldopa potentiates the pressor effects. Antipsychotics: Increased risk of extrapyramidal symptoms. Tolbutamine: Hypoglycaemic effects enhanced. Sex hormones: Antagonise hypotensive effect.
Servings: 
Adults: 250mg to 500mg orally 12hourly or 6hourly or 250mg to 500mg I.V. four times daily Children: 10mg/kg/day orally 12hourly or 6hourly or 20 to 40mg/kg/day I.V. in four divided doses

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