Generic Formulary
Cardio Vascular System
Sub Group: 
International Brand Name: 
250 MG
Unit of Packing: 
In treatment of: 
Management of Hyper Tension(HTN)
Adverse Effects: 
1.Sedation 2.Mental depression 3.Dryness of mouth, eyes & nose 4.Cognitive impairment 5.Impotence 6.Dizziness 7.Insomnia 8.Constipation 9.Electrolyte imbalance 10.Postural hypotension
1.Hypersensitivity to the drug 2.Hepatitis, Cirrhosis or other hepatic disorders 3.Depression 4.Pheochromocytoma 5.Postural hypotension 6.Porphyria 7.Concurrent administration with MAO inhibitors
Special Precaution: 
1.Renal impairment 2.Hepatic impairment 3.Haemolytic anaemia 4.Some individuals may show +ve direct coomb`s test 5.Parkinsonism 6.Asses blood count and liver function 7.Avoid driving or other jobs requiring mental concentration
Haloperidol: Adverse mental symptoms and high incidence of sedation. Levodopa: Effects of levodopa potentiated. Corticosteroids & Carbenoxolone: Antagonism of hypotensive effects. Propranolol: Paradoxical hypertensive effect. Diuretics: Enhanced hypotensive effect. Nitrates: Enhanced hypotensive effects. Sympathomimetics: Methyldopa potentiates the pressor effects. Antipsychotics: Increased risk of extrapyramidal symptoms. Tolbutamine: Hypoglycaemic effects enhanced. Sex hormones: Antagonise hypotensive effect.
Adults: 250mg to 500mg orally 12hourly or 6hourly or 250mg to 500mg I.V. four times daily Children: 10mg/kg/day orally 12hourly or 6hourly or 20 to 40mg/kg/day I.V. in four divided doses

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