METOCLOPRAMIDE HYDROCHLORIDE

Product: 
METOCLOPRAMIDE HYDROCHLORIDE
Formulary: 
Generic Formulary
Category: 
Gastrointestinal Tract
Sub Group: 
SEDATIVES, ANTISPASMODICS,PARKINETICS
International Brand Name: 
Maxolon,Reglan,Degan, Maxeran
Dosages: 
10 mg/ 5 mg/5ml
Unit of Packing: 
Tablets
In treatment of: 
Delayed Gastric emptying,Diabetic Gastroparess,Nausea,vomiting due to various causes except in motion sickness
Adverse Effects: 
1.Drowsiness 2.Confusion 3.Constipation 4.Muscle spasm 5.Tremor 6.Bronchospasm 7.Bradycardia 8.Fatigue 9.Headache 10.Dizziness 11.Nervousness 12.Sedation 13.Nausea 14.Rash
Contraiindication: 
1.Hypersensitivity to Metoclopramide 2.Gastrointestinal haemorrhage 3.Mechanical obstruction 4.Pheochromocytoma 5.Epilepsy 6.Parkinsonism 7.Pyloric stenosis 8.Previous history of dystonia
Special Precaution: 
1. Hypertension 2. Depression 3. Renal impairment 4. Hepatic impairment 5. Use with caution while driving vehicles, operating machines and people involving any other dangerous activities
Interaction: 
Anticholinergic drugs and narcotic analgesics: Effects on GI motility are antagonised by these drugs. Alcohol, sedatives, hypnotics, narcotics or tranquilizers: Additive sedative effect may occur. Digoxin, Cimetidine: Absorption of these drugs decreased. Acetaminophen, Aspirin: The absorption of these agents increased. Phenothiazines, Butyrophenone, Lithium and Thioxanthine drugs: May potentiate extrapyramidal effects. Bromocriptine: Antagonism of hypoprolactinaemic effect of bromocryptine. Cyclosporine: May lead to increased cyclosporine absorption, possibly increasing immunosupressive and toxic effect. Succinylcholine: Metoclopramide may increase the neuromuscular blocking effects of succinylcholine.
Servings: 
Adult: ORAL: 15 - 30 mg / day in 3 divided doses. Treatment of delayed gastric motility: 10 mg to be taken 30 minutes before each meal and at bed time for3 months. Drug is given depending upon the symptom being treated and clinical response. Gastroesophageal reflux: 10 - 15 mg 4 times a day, drug to be taken half an hour before each meal and at bed time. INJECTION: Post operative nausea and vomiting: 10 - 20 mg IM at the end of surgical procedure and repeat the dose every 4 - 6 hours if needed Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy: 2 - 4 mg / kg as IV infusion over 15 - 30 minutes. Maintenance dose: 3 - 5 mg / kg given over 8 hours Maximum dose: 10 mg / kg / day. Children: ORAL: 0.4 mg / kg / day in 4 divided doses.

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