METOPROLOL

Product: 
METOPROLOL
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTIANGINALS & CORONORY VASOLIDATORS
International Brand Name: 
Lopresor,Toprol XL,Selokeen,Metrol,Betaloc
Dosages: 
25 MG/50 mg/100 mg; 1 mg/ 1 ml/ 50 mg/100 mg
Unit of Packing: 
Tablets
In treatment of: 
Management of Angina Pectoris
Adverse Effects: 
1.Heart failure; 2.Nightmares;3.Gastrointestinal problems;4.Nausea;5.Tiredness;6.Sinus bradycardia;7.Depression;8.Rash;9.Hypotension;10.Dizziness;11.Fatigue;12.Vomiting;13.Diarrhoea;14.Headache;15.Bronchospasm
Contraiindication: 
1.Hypersensitivity to the drug; 2.Second or third degree heart block;3.Congestive heart failure;4.Cardiogenic shock;5.Bradycardia;6.Bronchial asthma;7.Diabetes mellitus
Special Precaution: 
1.Congestive heart failure;2.Hepatic impairment;3.The drug should be gradually withdraw with caution;4.Respiratory disorders
Interaction: 
Thioamines: Increased efficacy of metoprolol.Thyroid hormones: Decreased efficacy of metoprolol.Benzodiazepines: Increased efficacy of benzodiazepines.Clonidine: Abrupt withdrawal of clonidine may lead to hypertensive crisis.Ergot alkaloids: Peripheral ischaemia, possible peripheral gangrene.Lidocaine: Increased lidocaine level may occur leading to toxicity.Prazosin: Increased postural hypotension produced by parzosin.Sulphonylureas: Hypoglycaemic effects may be attenuated.
Servings: 
Oral -Adult: 50 to 450mg/dayHypertension: Starts with 50mg to 100mg/day once daily or in divided doses and gradually increases up to 450mg/day based on patient`s response;Arrhythmias:Oral: 100mg to 150mg/day in 2 to 3 divided doses;I.V.: Dose range: 10 to 15mg. Starts with 5mg infused within 5minutes. Then repeat the therapy with the same dose at every 5minutes interval based on patient`s response;Maximum dose: 20mg-Angina: 50mg twice daily, gradually increases based on patient`s response at one week intervals;Maximum dose: 0.4gm/day;Migraine: 0.1 to 0.2gm/day in divided doses in 12th hourly to 6th hourly.Prophylaxis of myocardial infarction: 0.1 to 0.2gm/day in divided dosesMyocardial infarction: 15mg in 3divided doses at 2minutes interval as I.V.bolus administration. Then 200mg orally in four divided doses for 2days.

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