Generic Formulary
Cardio Vascular System
Sub Group: 
International Brand Name: 
50 MG/150 Mg
Unit of Packing: 
In treatment of: 
Treatment of ventricular arrhythmias
Adverse Effects: 
Dizziness ; Confusion; Tremor; Ataxia; Blurred vision; Nausea; Vomiting; Hypotension; Accentuate AV; block; Bradycardia; Worsened arrhythmia; Palpitation; Chest pain; Altered liver function tests
Hypersensitivity to the drug ; Second or third degree AV block; Cardiogenic shock; Sinus node; dysfunction; Conduction disturbances; Recent myocardial infarction
Special Precaution: 
Hepatic impairment ; Renal impairment; Sinus node dysfunction; Heart failure; Hypotension; First degree heart block; Seizure disorders; Conduction defects
Aluminium / Magnesium hydroxide: Absorption of mexiletine slowed. Hydantoins, Rifampicin: Decreased plasma levels of mexiletine.Metoclopramide: Mexiletine absorption accelerated.Urinary acidifiers: In acidic urine, mexiletine clearance increased resulting in decreased serum levels. Urinary alkalizers: Increased serum levels of mexiletine.
Starts with a loading dose of 400mg. Followed by 200mg 3 - 4 times daily. Increase or decrease the dose in increments of 50 to 100mg every 2 to 3 days until satisfactory control is obtained.Maximum daily dose: 1200mg.

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