MIFETRISTONE

Product: 
MIFETRISTONE
Formulary: 
Generic Formulary
Category: 
Genito Urinary System
Sub Group: 
DRUGS ACTING ON UTERUS
International Brand Name: 
Dosages: 
200MG
Unit of Packing: 
Tablets
In treatment of: 
Cervical ripening,postcoital contraception,termination of pregnency (49 days or less duration),termination of pregnency up to 63 days,induction of labour following intrauterine foetal death, termination of pregnancy between 13-24 wk of gestation,softening and dilatation of cervix prior to surgical termination of pregnency
Adverse Effects: 
1.Dizziness 2.Headache 3.Diarrhea 4.Nausea 5.Vomiting 6.Back pain 7.Feeling tired 8.Hot flashes 9.Abdominal pain 10.Anorexia 11.Vginal bleeding 12.Bad-smelling vaginal discharge 13.Fainting 14.Irregular heartbeat 15.Palpitations 16.Chest pain 17.Fever 18.Redness, blistering, peeling or loosening of the skin, including inside the mouth 19.Skin rash 20.Uterine infections
Contraiindication: 
1.Hypersensitivity to Mifepristone 2.Ectopic pregnancy 3.Adrenal failure 4.Patient on long term corticosteroid therapy 5.Haemorrhagic disorder 6.Concurrent anticoagulant therapy 7.Inherited porphyria 8.Hepatic impairment 9.Renal impairment
Special Precaution: 
1.Asthma 2.Chronic obstructive pulmonary diseases 3.Cardiovascular diseases 4.Smoking 5.Alcoholism 6.Should be taken prior to and during surgical abortion to prevent rhesus immunisation.
Interaction: 
Ketoconazole, itraconazole, erythromycin, and grape fruit may inhibit mifepristone metabolism. Rifampicin, dexamethasone, phenytoin, phenobarbital, carbamazepine induce mifepristone`s metabolism.
Servings: 
Adult: 1.Cervical ripening: 50 - 600mg to be taken 24 - 30 hour before surgery. 2.Postcoital contraception: 600mg as single dose within 3 days after intercourse. 3.Once a month contraceptive pill: 200mg as single dose on the second day after mid cycle. 4.Termination of pregnancy up to 49 days: 600 mg as single dose and after 2 days takes Misoprostol 400mcg as single dose. 5.Termination of pregnancy up to 63days: 600 mg as single dose and after 36 - 48 hours take Gemeprost vaginally. 6.Termination of pregnancy between 13 - 24 weeks of gestation: 600mg as single dose to be taken 36 - 48 hours before prostaglandin therapy 7.Induction of labour following intrauterine fetal death: 600mg / day for 2 days. 8.Softening and dilatation of cervix before surgical termination of pregnancy: 600 mg as single dose is given 36 - 48 hours before surgery.

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