International Brand Name:
In treatment of:
Cervical ripening,postcoital contraception,termination of pregnency (49 days or less duration),termination of pregnency up to 63 days,induction of labour following intrauterine foetal death, termination of pregnancy between 13-24 wk of gestation,softening and dilatation of cervix prior to surgical termination of pregnency
12.Bad-smelling vaginal discharge
18.Redness, blistering, peeling or loosening of the skin, including inside the mouth
1.Hypersensitivity to Mifepristone
4.Patient on long term corticosteroid therapy
6.Concurrent anticoagulant therapy
2.Chronic obstructive pulmonary diseases
6.Should be taken prior to and during surgical abortion to prevent rhesus immunisation.
Ketoconazole, itraconazole, erythromycin, and grape fruit may inhibit mifepristone metabolism.
Rifampicin, dexamethasone, phenytoin, phenobarbital, carbamazepine induce mifepristone`s metabolism.
1.Cervical ripening: 50 - 600mg to be taken 24 - 30 hour before surgery.
2.Postcoital contraception: 600mg as single dose within 3 days after intercourse.
3.Once a month contraceptive pill: 200mg as single dose on the second day after mid cycle.
4.Termination of pregnancy up to 49 days: 600 mg as single dose and after 2 days takes Misoprostol 400mcg as single dose.
5.Termination of pregnancy up to 63days: 600 mg as single dose and after 36 - 48 hours take Gemeprost vaginally.
6.Termination of pregnancy between 13 - 24 weeks of gestation: 600mg as single dose to be taken 36 - 48 hours before prostaglandin therapy
7.Induction of labour following intrauterine fetal death: 600mg / day for 2 days.
8.Softening and dilatation of cervix before surgical termination of pregnancy: 600 mg as single dose is given 36 - 48 hours before surgery.