MINOCYCLINE

Product: 
MINOCYCLINE
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTIBACTERIALS
International Brand Name: 
Minomycin,Minocin, Cyclimycin,Dynocin, Aknemin,Sebomin, Mino-tabs,Arestin
Dosages: 
50 MG/ 100 mg
Unit of Packing: 
Capsuel
In treatment of: 
Treatment of susceptible infections;treatment of Acne;As part of alternative multidrugtherapy in Leprosy; treatment of susceptible infections
Adverse Effects: 
1.Vestibular toxicity 2.Intracranial hypertension 3.Headache 4.Dizziness 5.Vertigo 6.Vomiting 7.Nausea 8.Dysphagia 9.Epigastric distress 10.Glossitis 11.Elevated liver enzymes 12.Discoloration of teeth 13.Esophageal ulceration 14.Skin rashes 15.Pericarditis 16.Neutropenia 17.Eosinophilia 18.Retardation of bone growth
Contraiindication: 
1.Hypersensitivity to the drug or other tetracyclines 2.Hepatic impairment 3.Renal impairment
Special Precaution: 
1.Renal impairment: 2.Hepatic impairment: 3.Sun exposure may leads to phototoxicity
Interaction: 
Antacids (aluminium, calcium, zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of minocycline possibly reducing its efficacy. Anticoagulants: Increase the hypoprothrombinemic effects of anticoagulants. Cimetidine: Decreases GI absorption may lead to decreased efficacy. Digoxin: Increased serum levels leading to digoxin toxicity. Methoxyflurane: Nephrotoxic effects of both increased. Oral contraception: Breakthrough bleeding; pregnancy may occur. Penicillins: May interfere with bactericidal action of penicillin. Food: Some dairy products interfere with absorption of minocycline.
Servings: 
Adults: 0.2gm initial dose followed by 0.1gm twice daily or 0.05gm four times daily for a week to two weeks Acne: 0.05gm once daily to three times daily. Pleural effusion: 300mg in 50 ml sodium chloride injection Children (above 8 years of age): Initially 4 mg/kg/day in two divided doses followed by 2mg/kg/day twice daily.

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