MITOMYCIN

Product: 
MITOMYCIN
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
mutamycin
Dosages: 
2 mg/10 mg
Unit of Packing: 
Vial
In treatment of: 
Treatment of solid Tumours including Bladder,Breast,Cervix,Eye,Liver,Lung,Stomach and Prostate
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. Sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blood in urine or in stool 14. Cough or hoarseness 15. Fever 16. Chills 17. Lower back or side pain 18. Painful or difficult urination 19. Pinpoint red spot on skin 20. Slurred speech 21. Swelling on leg or lower leg 22. Shortness of breath 23. Bloody vomiting 24. Thinned or brittle hair 25. Mouth blistering 26. Thrombocytopenia 27. Leucopenia 28. Interstitial pneumonites 29. Septicemia 30. Delayed cumulative bone marrow suppression 31. Renal damage 32. Dermatitis 33. Stomatitis 34. Sterility
Contraiindication: 
1. Hypersensitivity to the drug 2. Hemorrhagic disorder 3. Thrombocytopenia 4. Renal impairment 5. Coagulation disorder 6. Vaccination 7. Bone marrow depression 8. Intramuscular and subcutaneous administrations are contraindicated.
Special Precaution: 
1. Leucopenia 2. Ulceration 3. Kidney disease 4. Infection 5. Chicken pox 6. Herpes zoster 7. Bleeding 8. Decreased platelet count
Interaction: 
Vinca alkaloids: Acute shortness of breath and severe bronchospasm have occured following the use of vinca alkaloids in patients who had previously or concurrently received mitomycin.
Servings: 
Intravenous- Adult- 10 to 20mg/metre square as a single dose every 4 to 8 weeks 2mg/metre square/day for 5 days. This cycle is repeated for 6 to 8 weeks

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