MITOXANTRONE

Product: 
MITOXANTRONE
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Novantrone
Dosages: 
20 mg/10 ml
Unit of Packing: 
Vial
In treatment of: 
Treatment of acute Lukaemia,Breast Cancer,Prostate Cancer and Lymphomas
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. Sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blue or green urine 14. Cough or hoarseness 15. Fever 16. Chills 17. Lower back or side pain 18. Painful or difficult urination 19. Pinpoint red spot on skin 20. Slurred speech 21. Swelling on leg or lower leg 22. Shortness of breath 23. Bloody vomiting 24. Thinned or brittle hair 25. Mouth blistering 26. Seizures 27. Conjunctivitis 28. Temporary blue colour to sclera 29. Heart failure 30. Arrhythmias 31. Renal failure 32. Myelosuppression 33. Jaundice 34. Hyperurecemia 35. Cough 36. Alopecia 37. Echymoses 38. Sepsis 39. Fungal infections
Contraiindication: 
1. Hypersensitivity to the drug 2. Severe Myelosuppression 3. Cardiac dysfunction
Special Precaution: 
1. Recent radiotherapy 2. Recent chemotherapy 3. Pre existing cardiac diseases 4. Hepatic impairment 5. Prior exposure to anthracyclines 6. Regularly monitor patient`s blood count and cardiac function
Interaction: 
Servings: 
Intravenous- Adult- For breast cancer and lymphoma 14mg/metre square every 3-4 weeks or 2-4mg/metre square/day for 5 days For acute non lymphocytic leukemia 12mg/metre square daily for 5 days Child- Intravenous- 8mg/metre square daily for 5 days every 3 to 4 weeks

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