NALTREXONE

Product: 
NALTREXONE
Formulary: 
Generic Formulary
Category: 
Poisonning and Drug Dependance
Sub Group: 
ALCOHOLISM
International Brand Name: 
Revia and Depade.Vivitrol
Dosages: 
50 mg
Unit of Packing: 
Tablets
In treatment of: 
Treatment of Opoid Dependance
Adverse Effects: 
1. Nausea 2. Vomiting 3. Abdominal pain 4. Constipation 5. Diarhoea 6. Headache 7. Anorexia 8. Insomnia 9. Anxiety 10. Nervousness 11. Depression 12. Increased thirst 13. Lethargy 14. Chest pain 15. Lymphocytosis 16. Muscle pain 17. Joint pain 18. Rashes 19. Fatigue 20. Sweating 21. Lacrimation 22. Delayed ejaculation 23. Decreased potency 24. Somnolence 25. Weight loss
Contraiindication: 
1. Hypersensitivity to Naltrexone 2. Patient on Opioid therapy 3. Acute opioid withdrawal 4. Liver failure
Special Precaution: 
1. Hepatic impairment 2. Renal impairment
Interaction: 
Disulfiram: The safety and efficacy of concomitant use of naltrexone and disulfiram has not been established. Concomitant use of two potentially hepatotoxic drugs is ordinarily not recommended. Thioridazine: Lethargy and somnolence have been reported when naltrexone and thioridazine have been used. Others: Patients taking naltrexone may not benefit from opioid containing medicines like cough and cold preparations, antidiarrhoeals and opioid analgesics. In an emergency, when opioid analgesia must be administered to a patient using naltrexone, the amount of opioid required might be greater than the usual dose and the resulting respiratory depression may be deeper and more prolonged.
Servings: 
Oral: Adult: Initial dose: 25 mg / day, Maintenance dose: 50mg/day or 350mg / week given in 3 alternate days. Alcoholism: Naltrexone 50 mg daily for 3 month

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