NELFINAVIR

Product: 
NELFINAVIR
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTIVIRALS
International Brand Name: 
Viracept
Dosages: 
250 MG
Unit of Packing: 
Tablets
In treatment of: 
HIV-1 infection combination treatment w/ other Antiretroviral Agents
Adverse Effects: 
1. Diarrhoea 2. Vomiting 3. Nausea 4. Abdominal pain 5. Confusion 6. Itching 7. Fatigue 8. Leucopenia 9. Thrombocytopenia
Contraiindication: 
1. Hypersensitivity to Nelfinavir
Special Precaution: 
1. Hepatic dysfunction 2. Haemophilia 3. Diabetes mellitus 4. Renal impairment
Interaction: 
Anti-arrhythmics : Increased risk of arrhythmias with amiodarone and quinidine (avoid concomitant use). Antibacterials : Rifampicin significantly reduces plasma concentration of nelfinavir (avoid concomitant use). Antidepressants: Plasma concentration reduced by St. John`s Wort. Antiepileptics : Carbamazepine and phenytoin possibly reduce plasma concentration of nelfinavir. Antihistamine: Increased risk of arrhythmias with terfenadine. Antipsychotics: Possibly increased risk of arrhythmias with pimozide. Anxiolytics and Hypnotics: Risk of prolonged sedation with midazolam. Barbiturates and Primidone: Phenobarbital possibly reduces plasma concentration of nelfinavir.
Servings: 
Adult: 2.25 g / day in 3 divided dose Children: 60 - 90 mg / kg body weight / day in 3 divided dose

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