NEOSTIGMINE

Product: 
NEOSTIGMINE
Formulary: 
Generic Formulary
Category: 
Musculo Skeletol Disorder
Sub Group: 
NEUROMUSCULAR DRUGS
International Brand Name: 
Prostigmin,Vagastigmin
Dosages: 
15 MG/0.5 mg/ml
Unit of Packing: 
Tablets
In treatment of: 
Treatment of Myasthaenia Gravis;treatment of paralytic Ileus and post operative Urinary retention
Adverse Effects: 
1. Erythmias 2. Hypotension 3. Tachycardia 4. AV block 5. Cardiac arrest 6. Syncope 7. Convulsions 8. Dizziness 9. Headache 10. Dysarthria 11. Dysfonia 12. GI disturbances, increased secretions 13. Skin rash 14. Thrombophlebitis 15. Muscle cramps & spasm 16. Laryngospasm 17. Respiratory depression 18. Urinary frequency and incontinence
Contraiindication: 
1. Hypersensitivity to the drug or any other ingredients of it 2. Mechanical urinary obstruction 3. Intestinal obstruction
Special Precaution: 
1. Epilepsy 2. Bronchial asthma 3. Bradycardia 4. Recent coronary occlusion 5. Hyperthyroidism 6. Cardiac disorders 7. Urinary retention 8. Peptic ulcer 9. Parkinson`s disease
Interaction: 
Aminoglycoside antibiotics: Neuromuscular blockade potentiated. Anticholinesterase drugs: In myasthenic patients receiving anticholinesterase muscle stimulants exercise caution since symptoms of anticholinesterase overdose (cholinergic crisis) may mimic under dosage (myasthenic weakness). Corticosteroids: Anticholinesterase effect of neostigmine blunted. Depolarising muscle relaxants: Neostigmine prolongs phase 1 block of these drugs. Magnesium: May antagonise the effects of neostigmine. Succinylcholine: Neuromuscular blocking effects enhanced- prolonged respiratory depression with extended periods of apnoea.
Servings: 
General dose - Oral- Adults- 15-30mg daily Intravenous- 1-5mg with atropine 0.4-1.25mg Children- I.M. /I.V. /SC- 0.01-0.04mg/kg every 2-3 hours Oral- 2 mg/kg/day divided every 3-4 hours. Note: Interval between 2 doses is important and should be individualized.

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