Infections & Infestations
International Brand Name:
In treatment of:
Treatment of infections caused by susceptible Bacteria
1. Hypersensitive to the drug or other amino glycosides
2. Renal impairment
3. Labyrinthine disorders
Aminoglycosides, vancomycin, methoxyflurane, enflurane, cephaloridine: Increased nephrotoxicity.
Loop diuretics: The auditory toxicity appears to be increased.
Polypeptide antibiotics: Concurrent use of these agents may increase risk of respiratory paralysis and renal dysfunction.
Anaesthetics, neuromuscular blocking agents (Tubocurarine, Gallamine): Risk of neuromuscular blockade and respiratory paralysis.
Pencillin, cephalosporins, carbenicillin, ticarcillin: Exert antibiotic synergism, especially useful in psuedomonas infections.
Lab tests: Aminoglycoside serum level: Guard against in vitro inactivation of aminoglycosides by beta-lactum antibiotics in patients on combination therapy.
Adults: 4 to 6 mg/kg/day in 1 to 3 divided doses. In severe infections dose may be increased up to 7.5mg/kg/day in 3 divided doses.
Children: 5.5 to 8 mg/kg/day in 2 - 3 divided doses.
Neonates: 4 to 6.5 mg/kg/day in 2 divided doses.
Urinary tract infections: 1.5 to 2mg/day in 2 divided doses.