NIFEDEPINE

Product: 
NIFEDEPINE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTI HYPERTENSIVE DRUGS
International Brand Name: 
Adalat,Nefedical,Procardia
Dosages: 
5MG/10 mg/20 mg
Unit of Packing: 
Tablets
In treatment of: 
Management of Hyper Tension(HTN)
Adverse Effects: 
1.Tachycardia 2.Palpitation 3.Hypotension 4.Nausea 5.Edema 6.Headache 7.Dizziness 8.Fatigue 9.Orthostatic hypotension 10.Leg cramps
Contraiindication: 
1.Acute myocardial infarction 2.Heart failure 3.Aortic stenosis 4.Hypotension 5.Cardiogenic shock 6.Hypersensitivity to the drug 7.Unstable angina 8.Coronary artery diseases
Special Precaution: 
1.Congestive heart failure 2.Cardiovascular insufficiency 3.Hypotension 4.Left ventricular outflow obstruction 5.Hepatic impairment 6.Slowly withdraw the drug with caution 7.Use cautiously along with other antihypertensive drugs 8.Diabetes mellitus
Interaction: 
Histamine H2 antagonists: Cimetidine and ranitidine enhance the bioavailability of nifedipine. Beta-blockers: Though advantageous in some, concomitant use results in increased adverse effects like bradycardia and conduction disturbances. Digitalis Glycosides: Increased serum digoxin levels with pssible toxicity. Magnesium Sulphate: With parenteral magnesium suplhate neuromuscular blockade and hypotension may occur. Theophyllines: Increased pharmacological effects of theophylline, resulting in toxicity. Quinidine: Hypotension, bradycardia, ventricular tachycardia, AV block and pulmonary oedema may occur. Serum quinidine levels may also be decreased by nifedipine. Anticoagulants: Increased prothrombin time. Fentanyl: Severe hypotension or increased fluid requirements.
Servings: 
Prinzmetal`s angina and Stable angina: Starts with 10mg 8th hourly. Increases the dosage up to 20mg 8th hourly. Further increases the dosage based on patient`s response at weekly intervals and repeat at 8th to 6th hourly. Maximum daily dose: 120mg Hypertension: 20mg twice daily or 30 to 60mg once daily extended release formulations. Adjust the dosage based on patient`s response.Maximum dose: 4omg twice daily Maximum dose for extended release formulations: 120mg/day Emergency reduction of blood pressure: Chew 10mg tablet and at the same time swallow another 10mg tablet. Repeat at every 20 to 30minutes. As Tocolytic: 10mg sublingually and repeat at 20minutes for 2 to 3 doses. Maintenance dosage: 10 to 20mg orally every 4 to 6 hours Children: For hypertensive emergencies: 250mcg to 500mcg/kg/dose 3 to 4 times daily.

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