ANTIANGINALS & CORONORY VASOLIDATORS
International Brand Name:
In treatment of:
Management of Angina Pectoris
13.Congestive heart failures
1.Acute myocardial infarction
6.Hypersensitivity to the drug
8.Coronary artery diseases
1.Congestive heart failure
4.Left ventricular outflow obstruction
6.Slowly withdraw the drug with caution
7.Use cautiously along with other antihypertensive drugs
Histamine H2 antagonists: Cimetidine and ranitidine enhance the bioavailability of nifedipine.
Beta-blockers: Though advantageous in some, concomitant use results in increased adverse effects like bradycardia and conduction disturbances.
Digitalis Glycosides: Increased serum digoxin levels with pssible toxicity.
Magnesium Sulphate: With parenteral magnesium suplhate neuromuscular blockade and hypotension may occur.
Theophyllines: Increased pharmacological effects of theophylline, resulting in toxicity.
Quinidine: Hypotension, bradycardia, ventricular tachycardia, AV block and pulmonary oedema may occur. Serum quinidine levels may also be decreased by nifedipine.
Anticoagulants: Increased prothrombin time.
Fentanyl: Severe hypotension or increased fluid requirements.
Prinzmetal`s angina and Stable angina: Starts with 10mg 8th hourly. Increases the dosage up to 20mg 8th hourly. Further increases the dosage based on patient`s response at weekly intervals and repeat at 8th to 6th hourly.
Maximum daily dose: 120mg
Hypertension: 20mg twice daily or 30 to 60mg once daily extended release formulations. Adjust the dosage based on patient`s response.Maximum dose: 4omg twice daily
Maximum dose for extended release formulations: 120mg/day
Emergency reduction of blood pressure: Chew 10mg tablet and at the same time swallow another 10mg tablet. Repeat at every 20 to 30minutes.
As Tocolytic: 10mg sublingually and repeat at 20minutes for 2 to 3 doses.
Maintenance dosage: 10 to 20mg orally every 4 to 6 hours
For hypertensive emergencies: 250mcg to 500mcg/kg/dose 3 to 4 times daily.