NITROFURANTION

Product: 
NITROFURANTION
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTIBACTERIALS
International Brand Name: 
Furadantin, Macrobid, Macrodantin, furatin
Dosages: 
50 MG
Unit of Packing: 
Tablets
In treatment of: 
Treatment of acute uncomplicated infections
Adverse Effects: 
1. Diarrhea 2. Dyspepsia 3. Abdominal pain 4. Nausea 5. Vomiting 6. Constipation 7. Drowsiness 8. Pruritus 9. Urticaria 10. Alopecia 11. Fever 12. Chills 13. Malaise 14. Pancreatitis 15. Pseudomembranous colitis 16. Peripheral neuropathy 17. Asthenia 18. Vertigo 19. Nystagmus 20. Headcahe 21. Dizziness 22. Hepatitis 23. Pulmonary sensitivity reactions 24. Angioedema.
Contraiindication: 
1. Hypersensitivity to Nitrofurantoin 2. Severe renal impairment 3. Anuria 4. Oliguria 5. Creatinine clearance below 60ml/minute
Special Precaution: 
1. Renal impairment 2. Anaemia 3. Electrolyte abnormalities 4. Diabetes mellitus 5. Vitamin B deficiency 6. G6PD deficiency
Interaction: 
Antichlolinergic drugs: Bioavailability of nitrofurantoin increased due to delayed gastric emptying. Probenecid: Decreased renal clearance and increased serum levels of nitrofurantoin resulting in toxicity. Magnesium trisilicate: May delay or decrease the absorption of nitrofurantoin. Food: Increases bioavailability of nitrofurantoin. Lab tests: Serum glucose decreased. Elevated serum bilirubin and alkaline phosphates. Elevated urinary creatinine levels. False-positive urinary glucose using benedicts reagent.
Servings: 
Oral : Adult: 200 - 400mg /day in 4 divided doses with food depending on the severity of infection dose is adjusted. Long term suppression therapy: 50 - 100mg at bed time Children above 12 year: same as adult dose. Children 1 month - 12 years: 5 - 7 mg / kg body weight / day in 4 divided doses Long term suppression therapy: 1 mg / kg / day at bed time

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