Infections & Infestations
International Brand Name:
4.Jarisch Herxheimer reaction
5.Pain at the site of injection
Hypersensitive to Penicillin G and other Penicillins
Renal impairment: monitor renal function and reduce the dose if needed
Aminoglycosides, parenteral: Certain parenteral penicillins may inactivate certain aminoglycosides in vitro - do not mix in the same IV solution.
Anticoagulants: Large IV doses of penicillins prolong bleeding time - chances of bleeding.
Oral contraceptives: Efficacy of oral contraceptives reduced. Additional form of contraception during penicillin therapy is advisable.
Heparin: With parenteral penicillins there is increased risk of bleeding.
Erythromycin: Both synergism and antagonism have been reported.
Allopurinol: Rate of ampicillin-induced skin rash appears much higher when co-administered with allopurinol.
Tetracyclines: Bacteriostatic effects of tetracycline derivatives may impair bactericidal effects of penicillins.
Probenecid: Prolongs half-life of penicillin.
Bacterial infections: 2-5lac units every 6hourly in divided dose depending on the severity of infection
Bacterial endocarditis: IV infusion 7-8g in divided dose every 6 hourly in a day depending on the severity of infection
Meningococcal disease: IV INFUSION 2-3 g six times a day
Premature infants and neonates: 100mg/kg daily in two divided dose
Infants (1 month): 150mg/kg thrice daily in divided dose
Child<12 years: 180-300mg/kg 4-6 times daily in divided dose.