OMEPRAZOLE

Product: 
OMEPRAZOLE
Formulary: 
Generic Formulary
Category: 
Gastrointestinal Tract
Sub Group: 
Hyper Acidity,Reflux,Ulcers
International Brand Name: 
Losec,prilosec
Dosages: 
10 MG/20 mg
Unit of Packing: 
Tablets
In treatment of: 
NSAID- Associated Duodenal or Gastric Ulcer and Gastroduodenal erosions
Adverse Effects: 
1. Diarrhoea 2. Nausea 3. Vomiting 4. Abdominal pain 5. Constipation 6. Flatulence 7. Headache 8. Dry mouth 9. Dizziness 10. Myalgia 11. Rash .
Contraiindication: 
1. Hypersensitivity to Omeprazole
Special Precaution: 
1. Hepatic impairment 2. Monitor gastric malignancy 3. Avoid prolonged use
Interaction: 
Diazepam: Half life of diazepam is increased. Phenytoin: Increased plasma concentration of phenytoin. Oral Anticoagulants: May prolong the elimination of warfarin. Cyclosporine, Disulfiram: Omeprazole interferes with the metabolism of these drugs. Ketaconazole, Ampicillin esters, Iron Salts: Omeprazole may interfere with the absorption of these drugs where gastric pH is a determinant of their bio-availability.
Servings: 
Oral : Adult: 10 - 20 mg / day to be taken before meals. Duodenal ulcer: 20 mg / day to be taken 30 minutes before meals for 1-2 months. Gastric ulcer: 20 mg / day for 1-2 months.In severe cases dose can be increased to 40 mg / day. Maintenance dose: 10 - 20 mg / day. Zollinger- Ellison syndrome: 60 mg / day increase the dose maximum up to 360 mg/ day in 3 divided doses if needed. Gastroesophageal reflux disease, oesophagitis: 20 mg / day for 1-2 months. Acid related dyspepsia: 10 - 20 mg / day for 1 month. NSAID associated ulceration: 20mg / day for 1 month. Prophylaxis of acid aspiration during anesthesia: 40 mg in the evening before the surgery and the same dose 2 - 6 hours before the procedure. Children: Not recommended

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