OXYTOCIN

Product: 
OXYTOCIN
Formulary: 
Generic Formulary
Category: 
Genito Urinary System
Sub Group: 
DRUGS ACTING ON UTERUS
International Brand Name: 
Pitocin,Syntocinon
Dosages: 
5U/0.5ML
Unit of Packing: 
Tablets
In treatment of: 
Ceasarian Section,3rd stage of Labour purperium,induction and augmentation of Labour; mgt of missed abortion,prevention of postpartum haemorrhage;treatment of postpartum haemorrhage
Adverse Effects: 
1. Hypersensitivity reaction 2. Premature ventricular contractions 3. Postpartum hemorrhage 4. Subarachnoid hemorrhage 5. Pelvic hematoma 6. Nausea 7. Vomiting 8. Cardiac arrhythmia 9. Hypertensive episodes 10. Fatal afibrinogenemia 11. Rupture of the uterus
Contraiindication: 
1. Hypersensitivity to Oxytocin 2. In unfavorable fetal positions (transverse lies, which are undeliverable without conversion prior to delivery) 3. In obstetrical emergencies 4. In fetal distress where delivery is not imminent 5. Where adequate uterine activity fails to achieve satisfactory progress 6. Where the uterus is already hyperactive or hypertonic 7. Invasive cervical carcinoma 8.Active herpes genitalis 9.Total placenta previa, vasa previa 10.Prolapse of the cord 11.Cephalopelvic disproportion
Special Precaution: 
1. 1st and 2nd stages of labor 2. Uterine surgery 3. Cervical surgery 4. Uterine sepsis 5. Grand multiparity 6. Overdistended uterus 7. Traumatic delivery 8. Invasive cervical cancer
Interaction: 
Sympathomimetics: Pressor effect of sympathomimetics may be increased leading to postpartum hypertension. Prostaglandins: Risk of uterine repture & cervical lacerations. Ergotamine: Synergistic effect in control of post partum haemorrhage.
Servings: 
Intravenous or intramuscular Adult: 1. Induction of labour: Initial dose: 0.5- 1 milliunits /minute as IV infusion and if needed rate can be gradually increased by 1 - 2 milliunits/minute until sufficient response is obtained. 2. Augmentation of labour: Initial dose: 2milliunits/minute as intravenous infusion and then gradually increase the dose maximum up to 20milliunits/minute 3. Reduction of postpartum bleeding after expulsion of placenta: 20 - 40 milliunits/minute as intravenous infusion after delivery of placenta. 4. Induce abortion: 10 - 100 milliunits/minutes 5. Oxytocin challenge test to assess fetal distress in high risk pregnancies greater than 31 weeks` gestation: Initial dose: 0.5milliunits/minute followed by gradual increase in infusion rate every 15 minutes up to 20milliunits/minute. When 3 moderate uterine contractions occur in a 10 minute interval then stop the use of medicament.

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