PACLITAXEL

Product: 
PACLITAXEL
Formulary: 
Generic Formulary
Category: 
Neoplastics
Sub Group: 
ANTI NEOPLASTIC AGENTS
International Brand Name: 
Taxol
Dosages: 
30 mg/100 mg/260mg
Unit of Packing: 
Inj
In treatment of: 
Treatment of Ovarian Carcinoma;Breast Cancer;Non-small Cell Lung Carcinoma
Adverse Effects: 
1. Nausea 2. Vomiting 3. Lowered resistance to infection 4. Bruising or unusual bleeding 5. Anemia 6. Weakness 7. Sore in mouth 8. Taste changes 9. Diarrhea 10. Loss of appetite 11. Visual changes 12. Black, tarry stools 13. Blood in urine or in stool 14. Cough or hoarseness 15. Fever 16. Chills 17. Lower back or side pain 18. Painful or difficult urination 19. Pinpoint red spot on skin 20. Slurred speech 21. Swelling on leg or lower leg 22. Shortness of breath 23. Bloody vomiting 24. Thinned or brittle hair 25. Mouth blistering 26. Thrombocytopenia 27. Leucopenia 28. Tachycardia 29. Bradycardia 30. Chest pain 31. Hypertension 32. Myalgia 33. Alopecia 34. Hepatic necrosis 35. Encephalopathy
Contraiindication: 
1. Hypersensitivity to the drug or polyoxyethylated castor oil 2. Baseline Neutropenia of 1<500cells/mm3 of blood
Special Precaution: 
1. Discontinue the therapy if there is hypotension, dyspnoea, angioedema or urticaria results during therapy. 2. Recent radiation 3. Hepatic impairment 4. Bone marrow depression
Interaction: 
Cisplatin: Given after cisplatin leads to profound myelosuppression. Ketoconazole: Inhibition of paclitaxel metabolism.
Servings: 
Intravenous- Adults- Metastatic ovarian cancer:135 or 175mg/metre square over 3 hours every 3 weeks - Breast cancer: 175mg/meter square over 3 hrs every 3 weeks Kaposi`s sarcoma: 135mg/metre square over 3 hours; repeat every 3 weeks OR 100mg/metre square over 3hrs; repeat every 2 weeks.

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