Generic Formulary
Nutrition & Metabolism
Sub Group: 
International Brand Name: 
30 MG/60 mg/90 mg
Unit of Packing: 
In treatment of: 
Paget's Disease;Hypercalcaemia of malingnancy
Adverse Effects: 
1. Fever 2. Pain at infusion site 3. Abdominal pain 4. Nausea 5. Vomiting 6. Anorexia 7. Constipation 8. Gastrointestinal haemorrhage 9. Generalised pain 10. Hypophosphataemia 11. Hypokalaemia 12. Hypocalcaemia 13. Hypomagnesaemia 14. Bone pain 15. Hypertension 16. Leukopenia
1. Hypersensitivity to Pamidronate and other biphosphonates
Special Precaution: 
1. Renal impairment 2. Monitor serum levels of calcium, phosphate, magnesium and potassium levels
Concomitant administration of a loop diuretic has no effect on the calcium lowering action of pamidronate.
Intravenous infusion: Adult: 30 - 90mg over 4 - 12 hours once/ day to once in 2 months depending on the condition Hypercalcaemia: Dose is depending on the severity and symptoms of Hypercalcaemia. Moderate Hypercalcaemia (corrected serum calcium level is 12 - 13.5 mg / dl): 60 - 90 mg over 2 - 24 hour Severe Hypercalcaemia (corrected serum calcium level more than 13.5 mg / dl): 90 mg over 2 - 24 hour Paget`s disease: 30mg over 4 hours for 3 consecutive days, total dose 90 mg Osteolytic bone lesions of multiple myeloma: 90mg over 4 hours/ month Osteoporosis: 30mg intravenous infusion over 3 hour every 3 months Oral: Post menopausal Osteoporosis:150 to 300mg daily Children: Not recommended

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