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PAMIDRONATE
Product:
PAMIDRONATE
Formulary:
Generic Formulary
Category:
Nutrition & Metabolism
Sub Group:
MINERALS RELATED DRUGS & OTHER NUTRITIONAL SUPPLE
International Brand Name:
Aredia.
Dosages:
30 MG/60 mg/90 mg
Unit of Packing:
Vial
In treatment of:
Paget's Disease;Hypercalcaemia of malingnancy
Adverse Effects:
1. Fever
2. Pain at infusion site
3. Abdominal pain
4. Nausea
5. Vomiting
6. Anorexia
7. Constipation
8. Gastrointestinal haemorrhage
9. Generalised pain
10. Hypophosphataemia
11. Hypokalaemia
12. Hypocalcaemia
13. Hypomagnesaemia
14. Bone pain
15. Hypertension
16. Leukopenia
Contraiindication:
1. Hypersensitivity to Pamidronate and other biphosphonates
Special Precaution:
1. Renal impairment
2. Monitor serum levels of calcium, phosphate, magnesium and potassium levels
Interaction:
Concomitant administration of a loop diuretic has no effect on the calcium lowering action of pamidronate.
Servings:
Intravenous infusion:
Adult:
30 - 90mg over 4 - 12 hours once/ day to once in 2 months depending on the condition
Hypercalcaemia: Dose is depending on the severity and symptoms of Hypercalcaemia.
Moderate Hypercalcaemia (corrected serum calcium level is 12 - 13.5 mg / dl): 60 - 90 mg over 2 - 24 hour
Severe Hypercalcaemia (corrected serum calcium level more than 13.5 mg / dl): 90 mg over 2 - 24 hour
Paget`s disease: 30mg over 4 hours for 3 consecutive days, total dose 90 mg
Osteolytic bone lesions of multiple myeloma: 90mg over 4 hours/ month
Osteoporosis: 30mg intravenous infusion over 3 hour every 3 months
Oral:
Post menopausal Osteoporosis:150 to 300mg daily
Children: Not recommended
