PERINDOPRIL

Product: 
PERINDOPRIL
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTI HYPERTENSIVE DRUGS
International Brand Name: 
Coversyl,Aceon
Dosages: 
2 MG/ 4 mg/8 mg
Unit of Packing: 
Tablets
In treatment of: 
Management of Hyper Tension(HTN)
Adverse Effects: 
1.Cough 2.Angioedema 3.Chest pain 4.Hyperkalemia 5.Rashes 6.Urticaria 7.Swelling of lips, mouth, nose, and larynx 8.Fetopathic in later half of pregnancy 9.Headache 10.Dizziness 11.Depression 12.Sleep disturbances 13.Diarrhoea 14.Anorexia 15.Nausea 16.Vomiting 17.Fatigue 18.Decreased haemoglobin count 19.Infections 20.Elevated liver enzymes 21.Acute renal failure is precipitated in renal artery stenosis
Contraiindication: 
1.Hypersensitivity to the drug 2.Renal artery stenosis 3.Aortic stenosis 4.Coarctation of aorta
Special Precaution: 
1.Renal impairment 2.Hepatic impairment 3.Ischaemic heart disease 4.Severe heart failure 5.Collagen vascular diseases 6.Angioedema 7.Cerebrovascular diseases 8.Lower dosage is needed for elderly
Interaction: 
Nitrates, Diuretics, Beta-blockers, Anti-depressants, Alcohol, Calcium channel blockers: Enhanced hypotensive effect. Potassium sparing diuretics: Hyperkalaemia. Sex hormones: Oestrogens and combined oral contraceptives antagonise hypotensive effect.
Servings: 
Starts with 4mg; orally once daily. Increases the dose to 8mg once daily or in two divided doses; after one month of therapy depending on patient`s response. Maximum dose: 16mg/day In CHF patients starts the dosage with 2mg once daily dosage and gradually increases at 1 to2 weeks` intervals to 4mg or further increase in dose depends up on patient`s response.

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