Musculo Skeletol Disorder
RUBAFACIENTS,TOPICAL ANALGESICS & TOPICAL NASAID
International Brand Name:
2. Heart burn
4. Epigastric distress
6. Skin rash
8. Aplastic anemia
10. Peptic ulceration
12. Liver enzyme elevation
1. Hypersensitivity to the drug
2. Active peptic ulcer
3. NSAID induced allergy
4. History of recurrent ulcer
5. Bronchial asthma
1. Severe hepatic impairment
2. Renal dysfunction
4. Recent surgery
5. Hemorrhagic disorders
Anticoagulants: May prolong prothrombin time.
Beta-Blockers: Antihypertensive effect may be impaired.
Cyclosporine: Nephrotoxicity of both agents may be increased.
Lithium: Serum lithium levels may be increased.
Hydantoins: Serum hydantoin levels increased resulting in increased pharmacologic and toxic effects.
Methotrexate: Risk of methotrexate toxicity (stomatitis, bone marrow suppression, nephrotoxicity) increased.
Probenecid: May increase the concentration and toxicity of piroxicam.
Aspirin: Displaces piroxicam from serum binding sites resulting in increased incidence of G.I. effects.
General dose - 20mg daily as a single dose
Musculo-skeletal disorders- Initially 40mg daily for 2 days then 20mg daily for 7-14 days.
Gout- Initially 40mg as a single then 40mg daily in single or divided doses for next 4-6 days.
Post-operative & post-traumatic pain- 40mg daily in single or divided doses for first two days, then 20mg once daily.
Primary dysmenorrhea- 40mg once daily for first two days, then 20mg once daily for 2-3 days.
Same as oral dose by deep I.M. injection into upper outer quadrant of buttocks. For maintenance use oral preparations
For Topical application:
Apply 1g gel to affected site 3-4 times daily. Review therapy after 4 weeks.