Poisonning and Drug Dependance
International Brand Name:
In treatment of:
Treatment of Organophosphorous Poisioning
9. Neuromuscular blockade (in high dose)
1.Hypersensitivity to Pralidoxime,
3.Overdose with Neostigmine or Physostigmine
Barbiturates: Use with caution in treatment of convulsions because barbiturates are potentiated by anticholinesterases.
Morphine, Theophilline, Aminophylline, Succinylcholine, Reserpine and Phenothiazines: Avoid in patients with organophosphorus poisoning.
Pralidoxime should be given only after Atropine injection (2-4 mg as IV).Pralidoxime 1-2 g in 100ml saline solution as IV infusion over 15 - 30 minutes or as IV injection in 5% water within 5 minutes. The dose may be repeated after 1 hour if needed and if muscle weakness continues then give the dose every 8 - 12 hours. Maximum total dose: 12 g in 24 hours.
Organic phosphorus chemical ("nerve gas") poisoning:
Adults: 600 mg as IM and dose may be repeated 15minutes after the first dose and if needed again 15minutes after the second dose.
Organophosphorous poisoning: 25 - 50 mg / kg body weight as IV injection. The dose may be repeated after 1 hour if needed and if muscle weakness again continues then give every 8 - 12 hours.