PRALIDOXIME

Product: 
PRALIDOXIME
Formulary: 
Generic Formulary
Category: 
Poisonning and Drug Dependance
Sub Group: 
CHELATING AGENT
International Brand Name: 
Dosages: 
500 mg/20 ml
Unit of Packing: 
Amp
In treatment of: 
Treatment of Organophosphorous Poisioning
Adverse Effects: 
1.Dizziness 2.Headache 3.Blurred vision 4.Diplopia 5.Tachycardia 6.Nausea 7.Drowsiness 8.Mild weakness 9. Neuromuscular blockade (in high dose)
Contraiindication: 
1.Hypersensitivity to Pralidoxime, 2.Carbamate poisoning 3.Overdose with Neostigmine or Physostigmine
Special Precaution: 
1.Myasthenia gravis 2.Renal dysfunction
Interaction: 
Barbiturates: Use with caution in treatment of convulsions because barbiturates are potentiated by anticholinesterases. Morphine, Theophilline, Aminophylline, Succinylcholine, Reserpine and Phenothiazines: Avoid in patients with organophosphorus poisoning.
Servings: 
Parenteral: Adult: Organophosphorous poisoning: Pralidoxime should be given only after Atropine injection (2-4 mg as IV).Pralidoxime 1-2 g in 100ml saline solution as IV infusion over 15 - 30 minutes or as IV injection in 5% water within 5 minutes. The dose may be repeated after 1 hour if needed and if muscle weakness continues then give the dose every 8 - 12 hours. Maximum total dose: 12 g in 24 hours. Organic phosphorus chemical ("nerve gas") poisoning: Adults: 600 mg as IM and dose may be repeated 15minutes after the first dose and if needed again 15minutes after the second dose. Children: Organophosphorous poisoning: 25 - 50 mg / kg body weight as IV injection. The dose may be repeated after 1 hour if needed and if muscle weakness again continues then give every 8 - 12 hours.

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