PRAVASTATIN

Product: 
PRAVASTATIN
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
LIPID LOWERING AGENTS
International Brand Name: 
Pravachol , Selektine
Dosages: 
10 MG/20 mg
Unit of Packing: 
Tablets
In treatment of: 
Treatment of Hypercholesterolaemia (Type IIA & II B). Hyper Lipoproteinaemias
Adverse Effects: 
1.Headache 2.Abdominal discomfort 3.Heart burn 4.Abdominal pain 5.Nausea 6.Dyspepsia 7.Flatulence 8.Constipation 9.Abnormal liver function tests 10.Abnormal thyroid function tests 11.Urinary abnormality 12.Rash 13.Pruritus 14.Photosensitivity 15.Fatigue 16.Myositis 17.Chest pain 18.Myopathy 19.Rhabdomyolysis 20.Upper respiratory tract infections
Contraiindication: 
1.Hypersensitivity to the drug 2.Active liver diseases 3.Persistent elevation of serum transaminase levels
Special Precaution: 
1.Monitor hepatic and liver function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level 2.History of liver diseases 3.Renal impairment 4.Alcoholics
Interaction: 
Bile Acid Sequestrants (BAS): When pravastatin is administered 1hour before or 4 hours after BAS, there is no clinically significant decrease in bioavailability or therapeutic effect. Gemfibrozil : Combination therapy generally not recommended.
Servings: 
Oral: Starts with 10mg to 20mg once daily; at bed time. Increased if required based on patients response. Maximum dose: 40mg

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