PREDNISOLONE

Product: 
PREDNISOLONE
Formulary: 
Generic Formulary
Category: 
Endocrine System
Sub Group: 
CORTICOSTEROIDS
International Brand Name: 
Dosages: 
4MG /16 MG
Unit of Packing: 
Tablets
In treatment of: 
Suppression of allergic and inflammatory responses,bronchial asthama,severe dermatological reactions
Adverse Effects: 
1.Susceptibility to infection 2.Peptic ulcer 3.Haemorrhage 4.Glycosuria 5.Hyperglycaemia 6.Osteoporosis 7.Atrophy of adrenal cortex(on prolonged therapy) 8.Suppression of adrenocorticotropic hormone 9.Cushing`s syndrome 10.Inhibition of growth in children 11.Amenorrhoea 12.Behavioral disturbances 13.Thromboembolic disorders 14.Myopathy 15.Weakness 16.Lymphocytopenia 17.Muscle wasting 18.Gastrointestinal discomfort 19.Increased appetite 20.Delayed wound healing 21.Headache 22.Euphoria 23.Insomnia 24.Seizures 25.Heart failure 26.Arrhythmias 27.Posterior sub capsular cataract 28.Glaucoma 29.Increased intracranial pressure
Contraiindication: 
1.Hypersensitivity to the drug 2.Peptic ulcer 3.Systemic Infections 4.Fungal infections 5.Live vaccines
Special Precaution: 
1.Avoid sudden discontinuation of the drug 2.Tuberculosis 3.Osteoporosis 4.Ocular herpes simplex 5.Primary glaucoma 6.Peptic ulcer 7.Primary psychosis and psychoneurosis 8.Recent myocardial infarction 9.Heart failure 10.Diabetes mellitus 11.Hypothyroidism 12.Cirrhosis 13.Stress 14.Sepsis 15.Hypertension 16.Myasthenia gravis 17.Renal impairment 18.Hepatic impairment 19.Non specific Ulcerative colitis 20.Diverticulitis 21.Recent intestinal anastomosis 22.Seizures 23.Thromboembolic disorders
Interaction: 
Barbiturates: Decrease pharmacologic of prednisolone. Oral contraceptives: May increase concentration of prednisolone. Oestrogens: May decrease the clearance of prednisolone. Ketoconazole: Increases efficacy of prednisolone. Rifampicin: Decreases efficacy. Prednisolone affects the actions of the following: Anticholinesterases: Effects may be antagonised in myasthenia gravis. Cyclosporine: May lead to enhanced toxicity. Digitalis glycosides: May lead to enhanced toxicity. Isoniazid: Decreased serum levels of isoniazid. Salicylates: Decreased serum levels of salicylate. Diuretics: May cuase hypokalaemia and increased hyperglycaemia. Non-depolarising muscle relaxants: Altered response. Somatrem: Growth promoting effect inhibited. Theophyllines: Altered response of either agent. IUCD: contraceptive failure. Lab. Tests: a) Increases serum cholesterol levels. b) Increases urine glucose levels. c) Decreases Thyroid I131 uptake; Decreases T3 serum levels. d) Decreases serum potassium.
Servings: 
Oral: 10 to 60mg/day; depending up on the severity of the condition and patient`s response. Children: 0.15 to 2mg/kg/day in 4 to 6 divided doses; depending up on the severity of the condition and patient`s response. I.M. or I.V.: 2 to 30mg 12th hourly Intra-articular: 5 to 25mg Prednisolone acetate.

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