PROMETHAZINE

Product: 
PROMETHAZINE
Formulary: 
Generic Formulary
Category: 
Allergy & Immunology
Sub Group: 
ANTI ALLERGICS
International Brand Name: 
Phenargan,Promethegan,Avomine,Legigan
Dosages: 
10 MG/ 25 mg
Unit of Packing: 
Tablets
In treatment of: 
Treatment of allergic condition
Adverse Effects: 
Tardive dyskinesia Extrapyramidal reactions Drowsiness Sedation Dizzines Hypotension Dry mouth Constipation .Blurred vision Agranulocytosis Photosensitivity Insomnia Weight gain Cholestatic jaundice
Contraiindication: 
Hypersensitivity to Promethazine .Comatose Blood dyscrasias Patient taking antidepressants Liver damage
Special Precaution: 
Renal impairment Hepatic impairment Cardiovascular disease Pheochromocytoma Hypocalcaemia Epilepsy Cholestatic jaundice Patient exposed to extreme heat or cold or phosphorus insecticides Ceribrovascular disorder Patient on ECT Reaction to Insulin Prostatic hyperplasia Glaucoma Peptic ulcer Slowly withdraw the drug with caution
Interaction: 
Alcohol: CNS depression, extrapyramidal reactions. Aluminium salts: Decrease efficacy. Antacids should be given 1 hour before or 2 hours after promethazine. Anticholinergics: Decrease efficacy and increase the anticholinergic side-effects of promethazine. Barbiturates: Decrease efficacy. Barbiturate anaesthetics: Increase frequency and severity of neuromuscular excitation and hypotension. Bromocriptine: Efficacy decreased by promethazine. Charcoal: Prevents absorption of promethazine. Lithium: Disorientation, unconsciousness and extrapyramidal symptoms. Meperidine: Excessive sedation and hypotension.TCAs: Serum concentration increased by promethazine. Propranolol: Increased plasma levels of both drugs.MAOIs: Additive orthostatic hypotensive effect. Lab tests: Pregnancy tests: False positive results.Plasma bound iodine (PBI): Increase in PBI occurs.
Servings: 
Adult: Motion sickness: 50 mg / day in 2 divided dose Allergy: 25 mg at bed time Nausea: 12.5 - 25 mg /day Sedation: 25 - 50 mg at bed time Children: Motion sickness: 12.5 - 25 mg / day Allergy: 6.25 - 12. 5 mg 3 times a day Sedation: 12.5 - 25 mg at bed time

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