PYRAZINAMIDE

Product: 
PYRAZINAMIDE
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTITUBERCULOUS
International Brand Name: 
Pyrazinamide,Tebrazid
Dosages: 
300MG/ 1 gm/500 mg/750mg
Unit of Packing: 
Tablets-Distab
In treatment of: 
Treatment of Tuberculosis
Adverse Effects: 
1. Nausea 2. Vomiting 3. Anorexia 4. Rash 5. Urticaria 6. Malaise 7. Arthralgia 8. Myalgia 9. Pruritis 10. Photosensitivity 11. Fever 12. Dysuria 13. Porphyria 14. Thrombocytopenia 15. Sideroblastic anaemia
Contraiindication: 
1. Hypersensitivity to Pyrazinamide 2. Severe hepatic diseases 3. Acute gout
Special Precaution: 
1. Diabetes mellitus 2. Renal impairment 3. Gout
Interaction: 
Uricosurics: Antagonism of effect of probenecid and sulphinpyrazone. INH: Significantly reduces INH serum concentrations. Anti-diabetic agents: Affects control of diabetes in diabetics.
Servings: 
Adult:15 - 30 mg / kg body weight/ day in single dose, maximum dose up to 3 g/ day or 50 - 70mg / kg body weight/ twice weekly Children: Same as adult dose

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