REPAGLINIDE

Product: 
REPAGLINIDE
Formulary: 
Generic Formulary
Category: 
Diabetes
Sub Group: 
ORAL ANTIDIABETICS & RELATED DRUGS
International Brand Name: 
Dosages: 
0.5 MG/1 mg/2 mg
Unit of Packing: 
Tablets
In treatment of: 
treatment of type Diabetes Mellitus
Adverse Effects: 
1. Mild headache 2. Dyspepsia 3. Arthralgia 4. Weight gain 5. Mild to moderate hypoglycaemia 6. Nausea 7. Vomiting 8. Back pain 9. Chest pain 10. Rhinitis 11. Bronchitis 12. Sinusitis 13. Upper respiratory tract infections 14. Urinary tract infections.
Contraiindication: 
1.Hypersensitivity to the drug 2.Type-1 diabetes mellitus 3.Diabetic ketoacidosis 4.Severe hepatic impairment
Special Precaution: 
1.Hepatic impairment 2.Malnourished and deliberate individuals 3.After severe exercise 4.Along with alcohol 5.Along with other glucose lowering drugs 6.In patients whose HbA1c is below 8% 7.Loss of control of blood glucose may occur with drug when patient is exposed to stress such as fever, trauma, infection, or surgery. In such situations stop the Repaglinide and administer insulin 8.Hypoglycaemia
Interaction: 
Ketoconazole, miconazole and erythromycin: Metabolism of repaglinide inhibited. Troglitazone, rifampicin, barbiturates and carbamazepine: Increase metabolism of repaglinide.
Servings: 
Oral: For patients not previously treated or whose HbA1c is below 8%; starts with 0.5mg 30minutes before meals. For patient`s previously treated with glucose lowering drugs and whose HbA1c is 8% or more starts with 1 to 2mg immediately 30minutes before each meals. Take 3 to 4 times a day based on changes in the patient`s meal pattern. Adjust dosage based on blood glucose response at weekly intervals. Maintenance dose: 0.25 to 4mg prior to meals. Maximum dose: 16mg/day.

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