RESERPINE

Product: 
RESERPINE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTI HYPERTENSIVE DRUGS
International Brand Name: 
Ecoplanet,Serpazide
Dosages: 
0.25 MG
Unit of Packing: 
Tablets
In treatment of: 
Management of Hyper Tension(HTN)
Adverse Effects: 
1.Excessive salivation 2.Nasal congestion 3.Cutaneous vasodilatation 4.Increased gut motility 5.Increased acidity 6.A-V conduction blocks 7.Orthostatic hypotension 8.Mental depression 9.Exacerbate epilepsy 10.Weight gain 11.Electrolyte imbalance 12.Parkinsonism 13.Gynecomastia 14.Impotence 15.Hypotension 16.Purpura 17.Thrombocytopenia
Contraiindication: 
1.Depression 2.In patients receiving electro convulsive therapy 3.Peptic ulcer 4.Ulcerative colitis 5.Parkinsonism 6.Pheochromocytoma 7.Thyrotoxicosis
Special Precaution: 
1.Tachycardia 2.Myocardial infarction 3.Arrhythmia 4.Bradycardia 5.Cardiac failure 6.Renal impairment 7.Hepatic impairment 6.Epilepsy
Interaction: 
Antihypertensives / Diuretics: Antihypertensive effects are enhanced. Digitialis and Quinidine: May result in cardiac arrhythmias. Ephedrine or Mephentermine: Hypertension may occur. General anaesthesia: Hypotension and bradycardia may occur. Levodopa: Signs and symptoms of Parkinsonism may be exacerbated. MAOIs: Should be avoided since it may result in hypertension. Sympathomimetics: Reserpine prolongs sympathomimetic response of direct acting and inhibits of indirect acting sympathomimetics. TCAs: Results in a response refractory to TCA therapy. Also hypotension, flushing, diarrhoea and manic reactions may occur. Lab tests: Increased serum prolactin levels, decreased urinary excretion of catecholamines, 17-ketosteroids, 17-hydroxycorticosteroids (17-OCHS) and vanillyl mandelic acid (VMA).
Servings: 
250 to 500mcg/day, gradually reduce to maintenance dose of 250mcg/day Maximum dose: 1mg to 1.5 mg

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