SALBUTAMOL + THEOPHYLLINE

Product: 
SALBUTAMOL + THEOPHYLLINE
Formulary: 
Generic Formulary
Category: 
Respiratory System
Sub Group: 
ANTIASTHAMATICS
International Brand Name: 
Dosages: 
2MG + 100MG; 1 Mg+500mg/5ml
Unit of Packing: 
Tablets
In treatment of: 
Releif of acute Bronchospasm
Adverse Effects: 
1. Upset stomach 2. Stomach pain 3. Diarrhea 4. Headache 5. Restlessness 6. Insomnia 7. Irritability 8. Vomiting 9. Increased or rapid heart rate 10. Irregular heartbeat 11. Seizures 12. Skin rash
Contraiindication: 
1. Hypersensitivity to the drug 2. Peptic ulcer 3. Underlying seizure disorders
Special Precaution: 
1. Cardiac disease 2. Hypertension 3. Hyperthyroidism 4. Hepatic impairment 5. Fever
Interaction: 
Benzodiazepines: Sedative effects may be antagonized. Beta agonists: Additive effect. Halothane: Catecholamine induced arrhythmias may occur. Tetracyclines: Theophylline adverse reaction may be enhanced. Food: Theophylline elimination is increased by a low carbohydrate, high protein diet.
Servings: 
Adults: Long term management of chronic bronchospasm: 300 to 1000 mg daily in divided doses in every 6 to 8 hrs or 175 to 500 mg every 12 hrs for modified release preparations. Bronchospasm- Adults- 5mg/kg body weight every 6 to 8 hrs. Children- 5 mg/kg every 4 to 6 hrs. Neonatal apnoea of prematurity- Child- More than 24days - 5mg/kg as maintenance dose and 1.5mg/kg every 12 hrs as loading dose. Less than 24 days- 1mg/kg every 12 hrs. Intravenous- Management of severe bronchospasm- Adult- 4 to 5 mg/kg as loading dose over 20 to 30 minutes. 0.4 mg/kg/hr as maintenance dose. Children- 4 to 5 mg/kg as loading dose over 20 to 30 minutes. 0.8mg/kg/hr as maintenance dose.

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