Generic Formulary
Sub Group: 
International Brand Name: 
Silvadene, Flamazine, Thermazene,
1 % W.W
Unit of Packing: 
In treatment of: 
Adjunctive prevention and treatment of infection in severe burns
Adverse Effects: 
1. Burning 2. Itching 3. Rashes 4. Systemic toxicity when applied on large surface area 5. Transient leucopenia (comes back to normal in 4 -5 days).
1. Hypersensitivity to Silver sulphadiazine and other Sulphonamide 2. Deep infections
Special Precaution: 
1. Renal impairment 2. Hepatic impairment 3. G6PD deficiency 4. Withdraw the drug immediately if rashes appears
Cyclosporine: Decreased efficacy and increased nephrotoxicity with cotrimoxazole. Methotrexate: Bone marrow depressant effect potentiated. Phenytoin: Half-life prolonged. Sulfonylureas: Increased hypoglycemic effect. Thiazide diuretics: Increased risk of thrombocytopenic purpura in elderly. Warfarin: Anticoagulant effect potentiated. Pyrimethamine: Megaloblastic anaemia. Oral contraceptives: Failure of oral contraceptives. Lab test: Interferes with serum methotrexate assay by the competitive binding protein technique (CBPA). Jaffe alkaline picrate reaction assay for creatinine: Overestimation of 10% of normal values. Topical proteolytic enzymes: Silver may inactivate such enzymes.
Adult: Silver sulphadiazine 1 % w/ w cream and 1% w/ v solution is used. Apply as a film of about 2 -3 mm thick directly to the burn or on a sterile gauze dressing. If needed reapply after complete removal of previous applications with saline.

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