Generic Formulary
Infections & Infestations
Sub Group: 
International Brand Name: 
100MG/ 50 mg
Unit of Packing: 
Inj- 1ml
In treatment of: 
Treatment of susceptible GM-Ve and Staphylococcal infections
Adverse Effects: 
1. Transient irritation in the eye 2.Ototoxicity
1. Hypersensitivity to Sisomicin and other Fluoroquinolones
Special Precaution: 
1. Prolonged use 2. Stop the use of medicaments if allergic reactions occur 3. Avoid contact lenses 4. Wear sun glasses if sensitivity to sunlight occurs
Aminoglycosides, Amphotericin B, Bacitracin, Cisplatin, Cephalothin, Vancomycin, Methoxyflurane Ethacrynic Acid, Frusemide, Bumetanide & Mannitol: Increased ototoxic, neurotoxic or nephrotoxic affects. Anaesthetics, Neuromuscular blocking agents (Tubocurarine, Gallamine): Risk of neuromuscular blockade and respiratory paralysis. Penicillin, Cephalosporins, Carbenicillin, Ticarcillin: Exert antibiotic synergism, especially useful in pseudomonas infections. Lab tests: Aminoglycoside serum levels: Guard against in-vitro inactivation of aminoglycosides by b-lactum antibiotics in patients on combination therapy.
The usual dose for adults is 3 mg/kg daily given intramuscularly in 2 or 3 divided doses. It may be given by intravenous infusion if necessary. Adult: 1 - 2 drop to be instilled in to the infected eye every 4-6 hours Trachoma: Treatment is for 1 - 2 months

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