SPIRONOLACTONE

Product: 
SPIRONOLACTONE
Formulary: 
Generic Formulary
Category: 
Genito Urinary System
Sub Group: 
DIURETICS
International Brand Name: 
Dosages: 
25 mg/100 mg
Unit of Packing: 
Tablets
In treatment of: 
Diagnosis and mgt of Hyperaldosteronism
Adverse Effects: 
1.Headache 2.Drowsiness 3.Nausea 4.Duodenal and gastric bleeding 5.Ulceration 6.Gynecomastia 7.Menstrual irregularities 8.Testicular atrophy 9.Ataxia 10.Impotence 11.Diarrhoea 12.Vomiting 13.Hyper kalemia 14.Hyponatraemia 15.Agranulocytosis 16.Altered levels of blood urea nitrogen 17.Gastro intestinal disturbances 18.Rashes 19.Ototoxicity
Contraiindication: 
1.Hypersensitivity to the drug 2.Hyper kalaemia 3.Anuria 4.Acute and progressive renal insufficiency
Special Precaution: 
1.Renal impairment 2.Hepatic impairment 3.Fluid and electrolyte imbalance
Interaction: 
ACE Inhibitors: Enhanced hypotensive effect; significant hyperkalaemia may occur. Digitalis glycosides: Interaction is complex and may result in increased serum digoxin levels & subsequent digitalis toxicity. Cyclosporin: Increased risk of hyperkalaemia. Potassium Preparations: May result in hyperkalaemia, possibly with cardiac arrhythmias or cardiac arrest, especially in patients with impaired renal functions. Salicylates: Diuretic effects reduced by salicylates. Carbenoxolone: Ulcer healing effect antagonised by spironolactone. Food: Increased absorption of spironolactone. Lab tests: Interferes with radio-immuno assay for measuring digoxin, resulting in falsely elevated serum digoxin.
Servings: 
Hypertension: 50 to 100mg/day in divided doses. Oedema: 25 to 200mg/day in divided doses. Diagnosis of primary hyperaldosteronism: 400mg/day (short test) or up to four weeks (long test) Hirsutism: 25 to 200mg/day in divided doses. Premenstrual syndrome: 25mg four times on fourteenth day of menstrual cycle. Acne: 100mg/day.

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