STREPTOMYCIN

Product: 
STREPTOMYCIN
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTIBACTERIALS
International Brand Name: 
Streptomycin Sulfate
Dosages: 
1GM/ 750 mg
Unit of Packing: 
Vial
In treatment of: 
Treatment of Tuberculosis
Adverse Effects: 
1. Damage to 8th cranial nerve & Ototoxicity 2. Rashes, Eosinophilia, Drug fever 3. Neuromuscular blockade 4. Nausea, Vomiting 5. Super infection with Candida & Staphylococcus aureus 6. Some degree of nephrotoxicity
Contraiindication: 
1.Hypersensitivity to amino glycosides 2.Labyrinthine disorders 3.Never administer I.V 4.Never use along with tetracycline & chloramphenicol 5.never use along with other nephrotoxic drugs
Special Precaution: 
1. Renal impairment 2. Neuromuscular disorders
Interaction: 
Aminoglycosides, Amphotericin B, Bacitracin, Cisplatin, Cephalothin, Vancomycin, Methoxyflurane Ethacrynic Acid, Frusemide, Bumetanide & Mannitol: Increased ototoxic, neurotoxic or nephrotoxic affects. Anaesthetics, Neuromuscular blocking agents (Tubocurarine, Gallamine): Risk of neuromuscular blockade and respiratory paralysis. Penicillin, Cephalosporins, Carbenicillin, Ticarcillin: Exert antibiotic synergism, especially useful in Pseudomonas infections. Lab tests: Aminoglycoside serum levels: Guard against in-vitro inactivation of aminoglycosides by b-lactum antibiotics in patients on combination therapy.
Servings: 
0.5 to 1gm daily; Given intramuscularly. Tuberculosis: Adults: 15 mg/kg /day for three months then continue the therapy with same dose twice or thrice in a week Children: 20 to 30 mg /kg/day in divided doses. Brucellosis: 1gm daily for 21 days along with tetracycline. Tularemia: 1 to 2gm IM for a week or more. Plague: 30mg/kg/day twice daily for 10 days. For better results streptomycin is combined with tetracycline or chloramphenicol Enterococcal infections: 1gm twice daily for two weeks; then 500mg twice daily for four weeks

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