Infections & Infestations
International Brand Name:
In treatment of:
Treatment of Tuberculosis
1. Damage to 8th cranial nerve & Ototoxicity
2. Rashes, Eosinophilia, Drug fever
3. Neuromuscular blockade
4. Nausea, Vomiting
5. Super infection with Candida & Staphylococcus aureus
6. Some degree of nephrotoxicity
1.Hypersensitivity to amino glycosides
3.Never administer I.V
4.Never use along with tetracycline & chloramphenicol
5.never use along with other nephrotoxic drugs
1. Renal impairment
2. Neuromuscular disorders
Aminoglycosides, Amphotericin B, Bacitracin, Cisplatin, Cephalothin, Vancomycin, Methoxyflurane Ethacrynic Acid, Frusemide, Bumetanide & Mannitol: Increased ototoxic, neurotoxic or nephrotoxic affects.
Anaesthetics, Neuromuscular blocking agents (Tubocurarine, Gallamine): Risk of neuromuscular blockade and respiratory paralysis.
Penicillin, Cephalosporins, Carbenicillin, Ticarcillin: Exert antibiotic synergism, especially useful in Pseudomonas infections.
Lab tests: Aminoglycoside serum levels: Guard against in-vitro inactivation of aminoglycosides by b-lactum antibiotics in patients on combination therapy.
0.5 to 1gm daily; Given intramuscularly.
Adults: 15 mg/kg /day for three months then continue the therapy with same dose twice or thrice in a week
Children: 20 to 30 mg /kg/day in divided doses.
1gm daily for 21 days along with tetracycline.
1 to 2gm IM for a week or more.
30mg/kg/day twice daily for 10 days. For better results streptomycin is combined with tetracycline or chloramphenicol
1gm twice daily for two weeks; then 500mg twice daily for four weeks