SULPHADIAZINE

Product: 
SULPHADIAZINE
Formulary: 
Generic Formulary
Category: 
Infections & Infestations
Sub Group: 
ANTIBACTERIALS
International Brand Name: 
Siver SULPHADIAZINE
Dosages: 
500MG
Unit of Packing: 
Tablets
In treatment of: 
Infections caused by susceptible Pathogens,Prophylaxis of Meningitis
Adverse Effects: 
1. Nausea 2. Vomiting 3. Diarrhoea 4. Abdominal pain 5. Headache 6. Anorexia 7. Pruritis 8. Erythema 9. Rash 10. Fever 11. Dizziness 12. Tinnitus 13. Hypersensitivity reaction 14. Bone marrow depression 15. Blood dyscrasias 16. Stevens-Johnson syndrome
Contraiindication: 
1. Hypersensitivity to Sulphasalazine and other salicylates.
Special Precaution: 
1. Hepatic impairment 2. Renal impairment 3. Blood dyscrasia 4. G6PD deficiency 5. Asthma
Interaction: 
Folic acid : Signs of folic deficiency with sulphasalazine. Digoxin : Possibly reduced efficacy of digoxin.
Servings: 
Oral: Dose should be adjusted according to the patient`s response and tolerance to the drug. Adult: Ulcerative colitis, Crohn`s disease: 1 g 3 - 4 times daily usually after meals Maintenance dose: 2 g / day in 4 divided doses should continue indefinitely. Rheumatoid arthritis: Initial dose: 1 g / day for 3-5 days, then gradually increase the dose up to 3 g/ day Children above 2 years: Ulcerative colitis, Crohn`s disease: 40 - 60 mg / kg body weight / day in 3 - 6 divided doses. Maintenance dose: 20 - 30 mg / kg body weight / day in 3 - 6 divided doses

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