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TACROLIMUS
Product:
TACROLIMUS
Formulary:
Generic Formulary
Category:
Immunosuppressants
Sub Group:
IMMUNOSUPPRESANTS
International Brand Name:
Plograf,Advagraf,Protopic
Dosages:
1 mg/ 5 mg
Unit of Packing:
Tablets
In treatment of:
Prevention of rejection in kidney graft transplant
Adverse Effects:
1. Blurred vision
2. Liver problems
3. Kidney problems
4. Seizures
5. Tremors
6. Hypertension
7. Hypomagnesemia
8. Diabetes mellitus
9. Hyperkalemia
10. Itching
11. Insomnia
12. Confusion
13. Loss of appetite
14. Hyperglycemia
15. Weakness
16. Depression
17. Cramps
18. Neuropathy
19. Herpes zoster infections
20. Polyoma viral infections
Contraiindication:
1. Hypersensitivity to the drug or any components of it
Special Precaution:
1. Heart disease
2. Kidney disease
3. Diabetes
Interaction:
Increased nephrotoxicity may result if tacrolimus is given with other potentially nephrotoxic drugs like cyclosporin.
Avoid concomitant use of potassium-sparing diuretics. Concomitant use of drugs which inhibit the cytochrome P450 (CYP3A) potentiate the effects of tacrolimus.
Servings:
Oral-
Kidney transplantation- 0.2mg/kg/day in adults as two divided doses.
Liver transplantation- 0.10-0.15mg/kg/day in two divided doses.
Maintenance dosage should be individualized so as to maintain whole blood concentration between 5-20 ng/ml.
Children- Generally need doses 1.5 to 2 times greater than those in adults.
