International Brand Name:
In treatment of:
Prevention of rejection in kidney graft transplant
1. Blurred vision
2. Liver problems
3. Kidney problems
8. Diabetes mellitus
13. Loss of appetite
19. Herpes zoster infections
20. Polyoma viral infections
1. Hypersensitivity to the drug or any components of it
1. Heart disease
2. Kidney disease
Increased nephrotoxicity may result if tacrolimus is given with other potentially nephrotoxic drugs like cyclosporin.
Avoid concomitant use of potassium-sparing diuretics. Concomitant use of drugs which inhibit the cytochrome P450 (CYP3A) potentiate the effects of tacrolimus.
Kidney transplantation- 0.2mg/kg/day in adults as two divided doses.
Liver transplantation- 0.10-0.15mg/kg/day in two divided doses.
Maintenance dosage should be individualized so as to maintain whole blood concentration between 5-20 ng/ml.
Children- Generally need doses 1.5 to 2 times greater than those in adults.