Generic Formulary
Sub Group: 
International Brand Name: 
1 mg/ 5 mg
Unit of Packing: 
In treatment of: 
Prevention of rejection in kidney graft transplant
Adverse Effects: 
1. Blurred vision 2. Liver problems 3. Kidney problems 4. Seizures 5. Tremors 6. Hypertension 7. Hypomagnesemia 8. Diabetes mellitus 9. Hyperkalemia 10. Itching 11. Insomnia 12. Confusion 13. Loss of appetite 14. Hyperglycemia 15. Weakness 16. Depression 17. Cramps 18. Neuropathy 19. Herpes zoster infections 20. Polyoma viral infections
1. Hypersensitivity to the drug or any components of it
Special Precaution: 
1. Heart disease 2. Kidney disease 3. Diabetes
Increased nephrotoxicity may result if tacrolimus is given with other potentially nephrotoxic drugs like cyclosporin. Avoid concomitant use of potassium-sparing diuretics. Concomitant use of drugs which inhibit the cytochrome P450 (CYP3A) potentiate the effects of tacrolimus.
Oral- Kidney transplantation- 0.2mg/kg/day in adults as two divided doses. Liver transplantation- 0.10-0.15mg/kg/day in two divided doses. Maintenance dosage should be individualized so as to maintain whole blood concentration between 5-20 ng/ml. Children- Generally need doses 1.5 to 2 times greater than those in adults.

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