TACROLIMUS

Product: 
TACROLIMUS
Formulary: 
Generic Formulary
Category: 
Skin
Sub Group: 
TOPICAL STEROID PREPARATION
International Brand Name: 
Prograf, Advagraf, and Protopic
Dosages: 
0.03% W/W/ 0.1% W/W
Unit of Packing: 
Tube- 10gm
In treatment of: 
ATOPIC DERMATITIS
Adverse Effects: 
1. Blurred vision 2. Liver problems 3. Kidney problems 4. Seizures 5. Tremors 6. Hypertension 7. Hypomagnesemia 8. Diabetes mellitus 9. Hyperkalemia 10. Itching 11. Insomnia 12. Confusion 13. Loss of appetite 14. Hyperglycemia 15. Weakness 16. Depression 17. Cramps 18. Neuropathy 19. Herpes zoster infections 20. Polyoma viral infections
Contraiindication: 
1. Hypersensitivity to the drug or any components of it
Special Precaution: 
1. Heart disease 2. Kidney disease 3. Diabetes
Interaction: 
Increased nephrotoxicity may result if tacrolimus is given with other potentially nephrotoxic drugs like cyclosporin. Avoid concomitant use of potassium-sparing diuretics. Concomitant use of drugs which inhibit the cytochrome P450 (CYP3A) potentiate the effects of tacrolimus.
Servings: 
Oral- Kidney transplantation- 0.2mg/kg/day in adults as two divided doses. Liver transplantation- 0.10-0.15mg/kg/day in two divided doses. Maintenance dosage should be individualized so as to maintain whole blood concentration between 5-20 ng/ml. Children- Generally need doses 1.5 to 2 times greater than those in adults.

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